Faculty of Science and Engineering, Musculoskeletal Science & Sports Medicine Research Centre, School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom.
School of Life Sciences, Queens Medical Centre, Nottingham, United Kingdom.
PLoS One. 2021 Nov 19;16(11):e0260491. doi: 10.1371/journal.pone.0260491. eCollection 2021.
Current investigations into physical behaviour in Muscular Dystrophy (MD) have focussed largely on physical activity (PA). Negative health behaviours such as sedentary behaviour (Physical Behaviour) and sitting time (Posture Classification) are widely recognised to negatively influence health, but by contrast are poorly reported, yet could be easier behaviours to modify.
14 ambulant men with MD and 12 healthy controls (CTRL) subjects completed 7-days of free-living with wrist-worn accelerometry, assessing physical behaviour (SB or PA) and Posture Classification (Sitting or Standing), presented at absolute (minutes) or relative (% Waking Hours). Participant body composition (Fat Mass and Fat Free Mass) were assessed by Bioelectrical Impedance, while functional status was assessed by 10 m walk test and a functional scale (Swinyard Scale).
Absolute Sedentary Behaviour (2.2 Hours, p = 0.025) and Sitting Time (1.9 Hours, p = 0.030 was greater in adults with MD compared to CTRL and Absolute Physical Activity (3.4 Hours, p < 0.001) and Standing Time (3.2 Hours, p < 0.001) was lower in adults with MD compared to CTRL. Absolute hours of SB was associated with Fat Mass (Kg) (R = 0.643, p < 0.05) in ambulatory adults with MD.
This study has demonstrated increased Sedentary Behaviour (2.2 hours) and Sitting time (1.9 Hours) in adults with MD compared to healthy controls. Extended waking hours in sitting and SB raises concerns with regards to progression of potential cardio-metabolic diseases and co-morbidities in MD.
目前对肌营养不良症（MD）中身体行为的研究主要集中在身体活动（PA）上。久坐行为（Physical Behaviour）和坐姿时间（Posture Classification）等负面健康行为广泛被认为会对健康产生负面影响，但与之相反的是，这些行为的报道却很少，而且可能更容易改变。
14 名肢体力弱的男性 MD 患者和 12 名健康对照（CTRL）受试者佩戴腕部加速度计完成了 7 天的自由生活，评估身体行为（SB 或 PA）和姿势分类（坐或站），以绝对（分钟）或相对（清醒小时的%）呈现。通过生物电阻抗评估参与者的身体成分（脂肪量和去脂体重），通过 10 米步行测试和功能量表（Swinyard 量表）评估功能状态。
MD 患者的绝对久坐时间（2.2 小时，p = 0.025）和坐姿时间（1.9 小时，p = 0.030）比对照组更大，而 MD 患者的绝对体力活动（3.4 小时，p < 0.001）和站立时间（3.2 小时，p < 0.001）比对照组更低。MD 患者的绝对 SB 小时数与脂肪量（kg）呈正相关（R = 0.643，p < 0.05）。
本研究表明，与健康对照组相比，MD 患者的久坐行为（2.2 小时）和坐姿时间（1.9 小时）增加。MD 患者在坐姿和 SB 中延长清醒时间，这令人担忧，因为这可能会导致潜在的心血管代谢疾病和合并症的进展。
