Nosrati Hamed, Seidi Farzad, Hosseinmirzaei Ali, Mousazadeh Navid, Mohammadi Ali, Ghaffarlou Mohammadreza, Danafar Hossein, Conde João, Sharafi Ali
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, 210037, China.
Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Adv Healthc Mater. 2022 Feb;11(3):e2102321. doi: 10.1002/adhm.202102321. Epub 2021 Dec 2.
An optimal radiosensitizer with improved tumor retention has an important effect on tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug-containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) are developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy is improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer.
一种具有改善肿瘤滞留性的最佳放射增敏剂对肿瘤放射治疗具有重要作用。在此，开发了金纳米颗粒（Au NPs）以及含药物的、mPEG共轭姜黄素（mPEG-CUR）自组装纳米颗粒（mPEG-CUR@Au），并在乳腺癌小鼠模型中作为药物载体和放射增敏剂进行评估。结果，通过应用一体化纳米颗粒实现同步放化疗，癌症治疗效果显著提高，评估细胞活力、增殖和活性氧生成的研究证明了这一点。体内抗癌实验表明，mPEG-CUR@Au系统提高了4T1乳腺癌的放射敏感性并完全消除了乳腺癌。
