前列腺素在炎症中的作用。
The role of prostaglandins in inflammation.
作者信息
Williams T J
出版信息
Ann R Coll Surg Engl. 1978 May;60(3):198-201.
Abstract
Our work suggests that aspirin-like drugs suppress inflammatory oedema not by reducing vessel wall permeability but by inhibiting the production of vasodilator mediators (prostaglandins), which results in a reduction in plasma exudation. Thus aspirin-like drugs appear to inhibit inflammatory swelling in the same manner as the traditional method of cooling with an ice-pack--by constricting the dilated blood vessels.
摘要
我们的研究表明，类阿司匹林药物抑制炎症性水肿并非通过降低血管壁通透性，而是通过抑制血管舒张介质（前列腺素）的产生，这导致血浆渗出减少。因此，类阿司匹林药物似乎与传统的用冰袋冷敷的方法一样，通过收缩扩张的血管来抑制炎症肿胀。
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The role of prostaglandins in inflammation.前列腺素在炎症中的作用。
Ann R Coll Surg Engl. 1978 May;60(3):198-201.
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Aspirin-like drugs and prostaglandins.阿司匹林类药物与前列腺素
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本文引用的文献
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Prostaglandins, aspirin-like drugs and analgesia.前列腺素、阿司匹林类药物与镇痛
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Inflammatory effects of prostaglandin D2 in rat and human skin.前列腺素D2在大鼠和人类皮肤中的炎症作用。
Br J Pharmacol. 1976 Feb;56(2):229-33. doi: 10.1111/j.1476-5381.1976.tb07446.x.
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Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.血栓素：一类从前列腺素内过氧化物衍生而来的新型生物活性化合物。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):2994-8. doi: 10.1073/pnas.72.8.2994.
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Role of prostaglandin endoperoxide PGG2 in inflammatory processes.前列腺素内过氧化物PGG2在炎症过程中的作用。
Nature. 1977 Jan 13;265(5590):170-3. doi: 10.1038/265170a0.
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.从动脉中分离出的一种酶可将前列腺素内过氧化物转化为一种抑制血小板聚集的不稳定物质。
Nature. 1976 Oct 21;263(5579):663-5. doi: 10.1038/263663a0.
10
Role of prostaglandin-mediated vasodilatation in inflammation.前列腺素介导的血管舒张在炎症中的作用。
Nature. 1977 Dec 8;270(5637):530-2. doi: 10.1038/270530a0.
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