Aksaray University Training and Research Hospital, Department of Hematology, Aksaray, Turkey.
Ortaköy State Hospital, Department of General Surgery, Aksaray, Turkey.
Transfus Apher Sci. 2022 Apr;61(2):103320. doi: 10.1016/j.transci.2021.103320. Epub 2021 Nov 18.
Whilst particular infectious bacteria are well-established to be associated with hematological diseases, more recent interest has focused on the entire microbial community of mucosal surfaces. In particular, the link between hematology and the microbiota (defined as the total assemblage of microorganisms in a mucosal environment)/ microbiome (i.e. the entire ecological habitat, including organisms, their genomes and environmental conditions) is becoming more well-known. Dysbiosis, or a change in the microbiome, has been linked to the development of neoplasms, infections, inflammatory illnesses, and immune-mediated disorders, according to growing data. Microbiota may influence distant tumor microenvironment through a variety of methods, including cytokine release control, dendritic cell activation, and T-cell lymphocyte stimulation. There are numerous major implications to study the microbiome in patients with benign and malignant hematologic disorders. In this review, we investigated the structure and function of the microbiome in patients with benign and malignant hematological diseases. Chemotherapy and immunosuppressive agents used in treatment of these benign and malignant hematological diseases may cause or exacerbate dysbiosis and infectious problems. After understanding the importance of microbiota in hematological diseases, we think that use of probiotics and dietary prebiotic substances targeting microbiota modification aiming to improve hematological disease outcomes should be investigated in future studies.
虽然某些特定的传染性细菌已被证实与血液系统疾病有关，但最近的研究兴趣集中在黏膜表面的整个微生物群落上。特别是，血液学与微生物群（定义为黏膜环境中微生物的总集合体）/微生物组（即整个生态栖息地，包括生物体、它们的基因组和环境条件）之间的联系越来越受到关注。越来越多的数据表明，微生物失调或微生物组的改变与肿瘤的发生、感染、炎症性疾病和免疫介导的疾病有关。微生物群可以通过多种方式影响远处的肿瘤微环境，包括控制细胞因子释放、树突状细胞激活和 T 淋巴细胞刺激。研究良性和恶性血液系统疾病患者的微生物组有许多重要意义。在这篇综述中，我们研究了良性和恶性血液系统疾病患者的微生物组的结构和功能。用于治疗这些良性和恶性血液系统疾病的化疗和免疫抑制药物可能导致或加重微生物失调和感染问题。在了解了微生物群在血液系统疾病中的重要性之后，我们认为应该在未来的研究中探讨针对微生物组修饰的益生菌和膳食益生元物质的使用，以改善血液系统疾病的预后。
