School of Psychology, Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou, 510631, China.
Cognitive Controland Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, 510515, China; Department of Psychiatry, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Neurosci Biobehav Rev. 2022 Jan;132:706-724. doi: 10.1016/j.neubiorev.2021.11.020. Epub 2021 Nov 18.
Stress abounds in daily life and is closely related to psychiatric disease. Less is known about the neural basis for the gender differences in stress, and the common and specific neural mechanism for physiological and psychosocial stress. The current study obtained 141 stress-oriented neuroimaging experiments from 126 eligible articles and sorted them into nine types of neuroimaging datasets based on the combination of stress (general, physiological or psychosocial) and gender (overall, male or female). An activation likelihood estimation (ALE) meta-analysis was conducted on each dataset to detect the spatial convergence of activations. A hierarchical clustering analysis was also conducted to uncover the relationship between the stress-induced paradigms and spatial distribution of brain activations. We found that the physiological stress and psychosocial stress showed common activation in the bilateral anterior insula and brainstem, but different activation likelihood in the bilateral insula, thalami, middle cingulate cortex, left fusiform gyri, and left amygdala. Men were more likely to activate the bilateral thalami during physiological stress, whereas women were more likely to activate the left amygdala during psychosocial stress. The activation patterns are more consistent among different physiological stress paradigms than psychosocial stress paradigms. Our results suggest that physiological stress and psychosocial stress activate common brain regions for movement and attentional regulation but different brain regions for sensory and affective processing.
日常生活中的压力与精神疾病密切相关。人们对性别差异与压力相关的神经基础以及生理和心理社会压力的共同和特定神经机制知之甚少。本研究从 126 篇符合条件的文章中获得了 141 项以压力为导向的神经影像学实验，并根据压力（一般、生理或心理社会）和性别（总体、男性或女性）的组合将其分为九种神经影像学数据集。对每个数据集进行激活似然估计 (ALE) 荟萃分析，以检测激活的空间收敛性。还进行了层次聚类分析，以揭示应激诱导范式与大脑激活的空间分布之间的关系。我们发现，生理应激和心理社会应激在双侧前岛叶和脑干中表现出共同的激活，但在双侧岛叶、丘脑、中扣带回皮质、左侧梭状回和左侧杏仁核中表现出不同的激活可能性。在生理应激期间，男性更有可能激活双侧丘脑，而女性在心理社会应激期间更有可能激活左侧杏仁核。不同的生理应激范式之间的激活模式比心理社会应激范式更一致。我们的结果表明，生理应激和心理社会应激激活了共同的大脑区域，用于运动和注意力调节，但用于感觉和情感处理的大脑区域不同。
