Guo Ling, Wu Hong, Li Qiang, Xu Chuan, Liu Yuyang
Department of Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
Medical School of Chinese PLA, Beijing 100853, China.
Zhongguo Fei Ai Za Zhi. 2021 Nov 20;24(11):796-803. doi: 10.3779/j.issn.1009-3419.2021.101.41.
Lung cancer is a leading cause of cancer-related morbidity and mortality globally, which is the biggest menace to the health and life of the population. Screening and early detection of lung cancer are effective in reducing its mortality, and the measurement of volatile organic compounds (VOCs) has become a promising clinical means for early detection, course detection and prognosis management of lung cancer, with advantages of rapid speed, non-invasiveness and convenience. Now, a variety of VOCs collection ways and analysis methods have emerged at home and abroad. This report summarized three aspects, including VOCs collection, multiple methods of analysis and progress in the diagnosis and treatment of lung cancer. At last, we discussed the limitations and prospects of VOCs analysis. .
肺癌是全球癌症相关发病和死亡的主要原因,是对人群健康和生命的最大威胁。肺癌的筛查和早期检测对于降低其死亡率是有效的,而挥发性有机化合物(VOCs)的检测已成为肺癌早期检测、病程监测和预后管理的一种有前景的临床手段,具有速度快、非侵入性和便捷等优点。目前,国内外出现了多种VOCs采集方式和分析方法。本报告总结了三个方面,包括VOCs采集、多种分析方法以及肺癌诊疗进展。最后,我们讨论了VOCs分析的局限性和前景。