Demir Eşref
Medical Laboratory Techniques Program, Department of Medical Services and Techniques, Vocational School of Health Services, Antalya Bilim University, Antalya Turkey.
Turk J Biol. 2021 Aug 30;45(4):559-569. doi: 10.3906/biy-2104-26. eCollection 2021.
The world urgently needs effective antiviral approaches against emerging viruses, as shown by the coronavirus disease 2019 (COVID-19) pandemic, which has become an exponentially growing health crisis. Scientists from diverse backgrounds have directed their efforts towards identifying key features of SARS-CoV-2 and clinical manifestations of COVID-19 infection. Reports of more transmissible variants of SARS-CoV-2 also raise concerns over the possibility of an explosive trajectory of the pandemic, so scientific attention should focus on developing new weapons to help win the fight against coronaviruses that may undergo further mutations in the future. offers a powerful and potential in vivo model that can significantly increase the efficiency of drug screening for viral and bacterial infections. Thanks to its genes with functional human homologs, could play a significant role in such gene-editing studies geared towards designing vaccines and antiviral drugs for COVID-19. It can also help rectify current drawbacks of CRISPR-based therapeutics like off-target effects and delivery issues, representing another momentous step forward in healthcare. Here I present an overview of recent literature and the current state of knowledge, explaining how it can open up new avenues for in our battle against infectious diseases.
2019年冠状病毒病（COVID-19）大流行已演变成一场呈指数级增长的健康危机，这表明世界迫切需要针对新兴病毒的有效抗病毒方法。来自不同背景的科学家致力于确定严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的关键特征以及COVID-19感染的临床表现。关于SARS-CoV-2更具传播性变体的报道也引发了对大流行可能呈爆发式发展的担忧，因此科学关注应集中在开发新武器，以助力打赢对抗未来可能会发生进一步突变的冠状病毒的战斗。 提供了一个强大且有潜力的体内模型，可显著提高针对病毒和细菌感染的药物筛选效率。由于其具有功能性人类同源物的基因， 在针对COVID-19设计疫苗和抗病毒药物的此类基因编辑研究中可能发挥重要作用。它还可以帮助纠正基于成簇规律间隔短回文重复序列（CRISPR）疗法当前的缺点，如脱靶效应和递送问题，这代表了医疗保健领域向前迈出的又一重要一步。在此，我概述近期文献及当前的知识状况，解释其如何能为我们对抗传染病的斗争开辟新途径。
