Ingram D M, Bennett F C, Willcox D, de Klerk N
University Department of Surgery, Queen Elizabeth II Medical Centre, Nedlands, Western Australia.
J Natl Cancer Inst. 1987 Dec;79(6):1225-9.
The hypothesis that dietary fat acts as a promotional agent for the development of breast cancer by influencing sex hormone levels was tested in a dietary intervention study. Thirty-three women in good health were randomly allocated to commence either a standard diet (deriving 40% of their energy from fat) or a low-fat diet (deriving 20% of their energy from fat). After 2 months, the women were crossed over to the alternative diet for another 2 months. Serum hormone and lipid levels were measured in the middle and at the end of each dietary period. In premenopausal women, the low-fat diet appeared to decrease levels of both non-protein-bound estradiol (1.48 down to 1.27%; P = .07) and non-protein-bound testosterone (1.06 down to 0.86%; P = .11). Cholesterol levels were lowered by the low-fat diet and were significantly associated with estradiol, testosterone, and dehydroepiandrosterone. High-density lipoprotein (HDL) cholesterol was associated with estradiol and prolactin. For the postmenopausal women, the low-fat diet lowered cholesterol and HDL cholesterol levels, but there were not the same associations with the hormones. These findings add weight to the concept that attention to diet may be a means of reducing the incidence of breast cancer in our community.
在一项饮食干预研究中，对饮食脂肪通过影响性激素水平而成为乳腺癌发展的促进因素这一假说进行了检验。33名健康女性被随机分配，开始采用标准饮食（其能量的40%来自脂肪）或低脂饮食（其能量的20%来自脂肪）。2个月后，这些女性交叉采用另一种饮食，再持续2个月。在每个饮食阶段的中期和末期测量血清激素和脂质水平。在绝经前女性中，低脂饮食似乎使非蛋白结合雌二醇水平（从1.48降至1.27%；P = 0.07）和非蛋白结合睾酮水平（从1.06降至0.86%；P = 0.11）均有所下降。低脂饮食降低了胆固醇水平，且胆固醇水平与雌二醇、睾酮和脱氢表雄酮显著相关。高密度脂蛋白（HDL）胆固醇与雌二醇和催乳素相关。对于绝经后女性，低脂饮食降低了胆固醇和HDL胆固醇水平，但与激素不存在同样的关联。这些发现进一步支持了这样一种观念，即关注饮食可能是降低我们社区乳腺癌发病率的一种手段。
