Rydmarker S, Nilsson P, Grenner J
Department of Otolaryngology, University of Lund, Malmö General Hospital, Sweden.
Acta Otolaryngol Suppl. 1987;441:3-23. doi: 10.3109/00016488709124798.
This paper describes a comparison between auditory threshold elevations and morphological cochlear changes evaluated with scanning electron microscopy in order to identify cochlear defects in guinea pigs exposed to impulse noise of varying durations. There was a significant difference in the auditory threshold shifts between animals exposed for 3 and 12 hours. Hair cell loss is generally used as a morphological correlate to noise-induced hearing loss. Minor stereocilia changes, quantified with non-standard statistical methods have been used as a complement. Morphologically, it was not possible to separate cochleas exposed to impulse noise for 3 and 12 hours when only lost hair cells were evaluated. Quantitative evaluation of subtle morphological changes are valuable in the correlation of noise-induced hearing loss with morphologic changes.
本文描述了通过扫描电子显微镜评估的听觉阈值升高与形态学耳蜗变化之间的比较,以便识别暴露于不同持续时间脉冲噪声的豚鼠的耳蜗缺陷。暴露3小时和12小时的动物之间的听觉阈值变化存在显著差异。毛细胞损失通常被用作噪声性听力损失的形态学关联指标。用非标准统计方法量化的轻微静纤毛变化已被用作补充。从形态学上看,当仅评估丢失的毛细胞时,无法区分暴露于脉冲噪声3小时和12小时的耳蜗。对细微形态学变化的定量评估对于噪声性听力损失与形态学变化的相关性具有重要价值。