In coming decades, artificial intelligence (AI) platforms are expected to build on the profound achievements demonstrated in research papers towards implementation in real-world medicine. The implementation of AI systems is likely to be as an adjunct to clinicians rather than a replacement, but it still has the potential for a revolutionary impact on ophthalmology specifically and medicine in general in terms of addressing crucial scientific, socioeconomic and capacity challenges facing populations worldwide. In this paper we discuss the broad range of skills that clinicians should develop or refine to be able to fully embrace the opportunities that this technology will bring. We highlight the need for an awareness to identify AI systems that might already be in place and the need to be able to properly assess the utility of their outputs to correctly incorporate the AI system into clinical workflows. In a second section we discuss the need for clinicians to cultivate those human skills that are beyond the capabilities of the AI platforms and which should be just as important as ever. We describe the need for such an awareness by providing clinical examples of situations that might in the future arise in human interactions with machine algorithms. We also envisage a harmonious future in which an educated human and machine interaction can be optimised for the best possible patient experience and care.