氧氟沙星与氯霉素在外眼感染治疗中的比较。
Ofloxacin compared with chloramphenicol in the management of external ocular infection.
作者信息
Bron A J, Leber G, Rizk S N, Baig H, Elkington A R, Kirkby G R, Neoh C, Harden A, Leong T
机构信息
Nuffield Laboratory of Ophthalmology, University of Oxford.
出版信息
Br J Ophthalmol. 1991 Nov;75(11):675-9. doi: 10.1136/bjo.75.11.675.
The safety and efficacy of 0.3% ofloxacin in treating bacterial ocular infections was compared with that of 0.5% chloramphenicol in a parallel-group, randomised clinical trial at five sites. Clinical and microbiological improvement rates were studied in 84 culture-positive patients. Patients with suspected bacterial ocular infections were evaluated for clinical improvement and were included in drug safety and comfort analyses. Clinical improvement did not differ significantly between drug treatments. All patients completing the study (79 assigned ofloxacin, and 74 chloramphenicol) showed clinical improvement. Clinical improvement in the culture-positive groups was 100% (41/41) after ofloxacin treatment, and 95% (41/43) after chloramphenicol treatment. Microbiological improvement rates were similar for the two drugs: 85% (33/39) improved with ofloxacin, and 88% (38/43) improved with chloramphenicol. Both drugs were well tolerated. Adverse reactions possibly due to the study medication occurred in 1% (1/89) of those who received ofloxacin, and in 4% (4/93) of those who received chloramphenicol.
在一项平行组随机临床试验中，于五个地点对0.3%氧氟沙星治疗细菌性眼部感染的安全性和有效性与0.5%氯霉素进行了比较。对84例培养阳性患者的临床和微生物学改善率进行了研究。对疑似细菌性眼部感染的患者评估其临床改善情况，并纳入药物安全性和舒适度分析。药物治疗之间的临床改善无显著差异。所有完成研究的患者（79例分配使用氧氟沙星，74例使用氯霉素）均显示出临床改善。氧氟沙星治疗后培养阳性组的临床改善率为100%（41/41），氯霉素治疗后为95%（41/43）。两种药物的微生物学改善率相似：氧氟沙星治疗后85%（33/39）改善，氯霉素治疗后88%（38/43）改善。两种药物耐受性均良好。接受氧氟沙星治疗的患者中1%（1/89）发生可能与研究用药有关的不良反应，接受氯霉素治疗的患者中4%（4/93）发生此类不良反应。
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