Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Head Neck. 2022 Feb;44(2):548-561. doi: 10.1002/hed.26940. Epub 2021 Nov 22.
To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10-1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63-0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70-1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.
进行一项系统评价，重点关注年轻患者（≤40 岁）与老年患者（>40 岁）口腔鳞状细胞癌（OSCC）的预后比较。我们的检索策略使用了四个数据库。首先，使用 Covidence 在线平台对所有标题进行系统整理。在第二阶段，由两位评审员独立分析了 118 篇可能合格的研究全文。有 12 项研究被认为符合数据提取标准。年轻组的复发率高于对照组（汇总相对风险（RR）=1.31；95%可信区间[1.10-1.56]）。年轻组的 5 年无病生存率（DFS）更差（汇总风险比（HR）=0.73；95%可信区间[0.63-0.85]），但两组的 5 年总生存率（OS）估计相似（汇总 HR=0.84；95%可信区间[0.70-1.00]）。尽管两组的 5 年 OS 相似，但≤40 岁的 OSCC 患者的复发数量和 5 年 DFS 更差。
