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头颈部癌症患者吞咽困难的健康风险:一项多中心前瞻性观察研究。

The health risks of dysphagia for patients with head and neck cancer: a multicentre prospective observational study.

机构信息

Department of Experimental and Clinical Medicine, Maxillofacial Surgery Unit, "Magna Graecia" University, Viale Europa, 88100, Catanzaro, Italy.

Department of Health Science, Nutrition Unit, "Magna Graecia" University, Viale Europa, 88100, Catanzaro, Italy.

出版信息

J Transl Med. 2021 Nov 22;19(1):472. doi: 10.1186/s12967-021-03144-2.

Abstract

It is well known that malnutrition is a frequent co-morbidity in cancer patients, especially in those with head and neck neoplasms. This may be due both to the presence of dysphagia symptoms and to the appearance of adverse effects on chemotherapy and / or radiotherapy. The aim of this retrospective observational multicentric study is to evaluate the nutritional status between dysphagia cancer patients and non-dysphagia cancer patients. Data from 60 patients were analysed, 31 of which without dysphagia and 29 with dysphagia. Results highlight that patients with dysphagia had higher involuntary body weight loss than non-dysphagia ones (p < 0.001). By analysing the entire population, it stands out a weight loss rate of 12 ± 9% compared to the usual weight was observed and a prevalence of moderate / severe malnutrition diagnosis of 53%. Furthermore, 76% of the population who manifested the symptom of dysphagia presented severe malnutrition already at the first visit, compared to 32% of non-dysphagia subjects.

摘要

众所周知,营养不良是癌症患者的常见合并症,尤其是头颈部肿瘤患者。这可能是由于存在吞咽困难症状以及化疗和/或放疗出现不良反应所致。本回顾性观察性多中心研究旨在评估吞咽困难和非吞咽困难癌症患者之间的营养状况。对 60 名患者的数据进行了分析,其中 31 名无吞咽困难,29 名有吞咽困难。结果表明,吞咽困难患者的非自愿体重减轻比非吞咽困难患者更为严重(p<0.001)。通过对整个人群进行分析,与通常体重相比,观察到体重减轻率为 12±9%,中度/重度营养不良的诊断率为 53%。此外,在首次就诊时,出现吞咽困难症状的人群中,有 76%已经存在严重营养不良,而非吞咽困难人群中这一比例为 32%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299f/8607588/5d26d0aad5d9/12967_2021_3144_Fig1_HTML.jpg

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