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痛风样关节炎伴痴呆患者的巨细胞动脉炎。

Polymyalgia Rheumatica in a Patient with Pseudogout and Dementia.

机构信息

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

Department of General Medicine, Chiba University, Chiba, Japan.

出版信息

Am J Case Rep. 2021 Nov 23;22:e933926. doi: 10.12659/AJCR.933926.

Abstract

BACKGROUND The differential diagnosis of generalized pain includes reactivity associated with bacterial and viral infections, autoimmune rheumatic disease, and orthopedic diseases. Obtaining a detailed medical history and establishing an accurate diagnosis are difficult in elderly patients with dementia. In addition, the differential diagnosis between polymyalgia rheumatica and pseudogout is often difficult. Thus, in our work, we examined the importance of interviewing the family of an elderly patient with dementia. CASE REPORT We report the case of an 88-year-old woman with dementia and a history of recurrent pseudogout who presented with a 12-day history of fever and generalized pain. Physical examination findings revealed warmth and swelling in the shoulder joints and right knee. Blood tests indicated increased inflammatory marker levels. The primary working impression was oligo-articular pseudogout. Based on family interview, the patient was seen to manifest atypical symptoms, including movement difficulty. Joint ultrasound findings showed inflammation of the left long head of the biceps attachment. Further, right knee arthrocentesis detected no calcium pyrophosphate crystals. After obtaining a detailed medical history from the patient's family and conducting other diagnostic tests, the patient was finally diagnosed with polymyalgia rheumatica, rather than oligo-articular pseudogout, with rapid improvement after undergoing low-dose prednisolone treatment. CONCLUSIONS Family interviews can be helpful for obtaining correct diagnosis in elderly patients with dementia.

摘要

背景

全身性疼痛的鉴别诊断包括与细菌和病毒感染、自身免疫性风湿病和骨科疾病相关的反应。在患有痴呆症的老年患者中,获取详细的病史和做出准确的诊断是困难的。此外,巨细胞动脉炎和假性痛风的鉴别诊断通常也很困难。因此,在我们的工作中,我们研究了对老年痴呆症患者家属进行访谈的重要性。

病例报告

我们报告了一例 88 岁患有痴呆症和复发性假性痛风病史的女性患者,其出现发热和全身性疼痛 12 天。体格检查发现肩关节和右膝关节发热和肿胀。血液检查显示炎症标志物水平升高。初步的印象是少关节假性痛风。根据家族访谈,患者表现出不典型的症状,包括活动困难。关节超声检查显示左侧肱二头肌长头附着处有炎症。此外,右膝关节穿刺术未检测到焦磷酸钙晶体。在从患者家属获取详细病史并进行其他诊断性检查后,最终诊断为巨细胞动脉炎,而非少关节假性痛风,经小剂量泼尼松龙治疗后迅速改善。

结论

家族访谈有助于对患有痴呆症的老年患者做出正确诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2a/8628562/b81783fc9287/amjcaserep-22-e933926-g001.jpg

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