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Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque.

作者信息

Li Yi, Zhu Huan, Zhang Qianyu, Han Ximeng, Zhang Zhenqian, Shen Linghong, Wang Lixin, Lui Kathy O, He Ben, Zhou Bin

机构信息

Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

出版信息

Cell Discov. 2021 Nov 23;7(1):111. doi: 10.1038/s41421-021-00328-4.

DOI:10.1038/s41421-021-00328-4
PMID:34811358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8608914/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f274/8608914/9e0c5e0c363b/41421_2021_328_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f274/8608914/9e0c5e0c363b/41421_2021_328_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f274/8608914/9e0c5e0c363b/41421_2021_328_Fig1_HTML.jpg

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Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.单细胞基因组学揭示了平滑肌细胞表型转换过程中的一种新型细胞状态,以及在小鼠和人类动脉粥样硬化中的潜在治疗靶点。
Circulation. 2020 Nov 24;142(21):2060-2075. doi: 10.1161/CIRCULATIONAHA.120.048378. Epub 2020 Sep 23.
2
Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.干细胞多能性基因 Klf4 和 Oct4 调节晚期动脉粥样硬化病变发病机制中关键的复杂 SMC 表型变化。
Circulation. 2020 Nov 24;142(21):2045-2059. doi: 10.1161/CIRCULATIONAHA.120.046672. Epub 2020 Jul 17.
3
动脉粥样硬化中的慢性炎症与血管细胞可塑性
Nat Cardiovasc Res. 2024 Dec;3(12):1408-1423. doi: 10.1038/s44161-024-00569-y. Epub 2024 Dec 9.
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The two coin sides of bacterial extracellular membrane nanovesicles: atherosclerosis trigger or remedy.细菌细胞外膜纳米囊泡的两个方面:动脉粥样硬化的诱因还是疗法。
Discov Nano. 2024 Nov 12;19(1):179. doi: 10.1186/s11671-024-04149-8.
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