Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Deparment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Cardiovasc Res. 2018 Mar 15;114(4):492-500. doi: 10.1093/cvr/cvx251.
Advances in lineage-tracking techniques have provided new insights into the origins and fates of smooth muscle cells (SMCs) in atherosclerosis. Yet new tools present new challenges for data interpretation that require careful consideration of the strengths and weaknesses of the methods employed. At the same time, discoveries in other fields have introduced new perspectives on longstanding questions about steps in atherogenesis that remain poorly understood. In this article, we address both the challenges and opportunities for a better understanding of the mechanisms by which cells appearing as or deriving from SMCs accumulate in atherosclerosis.
谱系追踪技术的进步为动脉粥样硬化中平滑肌细胞（SMC）的起源和命运提供了新的见解。然而，新工具为数据解释带来了新的挑战，需要仔细考虑所使用方法的优缺点。与此同时，其他领域的发现为动脉粥样发生过程中一些仍然知之甚少的长期存在的问题提供了新的视角。在本文中，我们既讨论了更好地理解作为或来源于 SMC 的细胞在动脉粥样硬化中积累的机制所面临的挑战，也讨论了其中的机遇。
