Università del Piemonte Orientale UPO, Novara, Italy.
"AOU Maggiore Della Carità", Novara, Italy.
Sci Rep. 2021 Nov 22;11(1):22666. doi: 10.1038/s41598-021-01215-4.
Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363-369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
许多 2019 冠状病毒病（COVID-19）幸存者在急性疾病后数月仍有症状。本研究旨在描述 COVID-19 患者出院一年后的临床演变。我们对 2020 年因 COVID-19 肺炎住院的 238 例患者进行了前瞻性队列研究，这些患者在 COVID-19 后已经进行了 4 个月的临床随访。200 名患者同意参加为期 12 个月的临床评估，包括：肺一氧化碳弥散功能（DLCO）的肺功能检查；创伤后应激（PTS）症状通过事件影响量表（IES）评估；运动功能评估（通过简短身体表现电池和 2 分钟步行测试）；胸部计算机断层扫描（CT）。在 366[363-369]天后，79 名患者（39.5%）报告至少有一种症状。96 名患者（49.0%）的 DLCO<80%。20 名患者（10.2%）报告严重的 DLCO 损伤（<60%），与 CT 扫描异常的程度有关。25.8%的患者存在一定程度的运动功能障碍。37/200 名患者（18.5%）表现出中度至重度 PTS 症状。在出院后 4 至 12 个月的时间里，运动功能有所改善，而呼吸功能没有改善，同时伴有肺结构损伤的证据。急性疾病一年后，症状仍然高度普遍存在。
