耳部和鼻部组织中氧氟沙星的浓度。
Concentrations of ofloxacin in ear and nasal tissues.
作者信息
Tolsdorff P
机构信息
ENT Department, Kath. Krankenhaus Siebengebirge, Bad Honnef, Federal Republic of Germany.
出版信息
Eur Arch Otorhinolaryngol. 1993;250 Suppl 1:S7-11. doi: 10.1007/BF02540109.
The results of two kinetic studies examining soft tissue, cartilage and bone after uptake of oral ofloxacin [administered as 200 mg twice daily (study I/nose) or 400 mg once daily (study II/ear)] show that antibiotic concentrations lie within the therapeutic range. Findings demonstrate that 400 mg ofloxacin daily is a compliance-enhancing and effective approach to the treatment of ENT-related infections, in particular those caused by problem organisms such as Pseudomonas aeruginosa.
两项动力学研究的结果显示，口服氧氟沙星（分别为每日两次，每次200毫克，研究I/鼻部；或每日一次，每次400毫克，研究II/耳部）后，软组织、软骨和骨骼中的抗生素浓度处于治疗范围内。研究结果表明，每日400毫克氧氟沙星是一种提高依从性且有效的治疗耳鼻喉相关感染的方法，尤其是针对由铜绿假单胞菌等难处理病原体引起的感染。
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