Kazmierczak A, Pechinot A, Duez J M, Haas O, Favre J P
University Hospital, Dijon.
Drugs. 1987;34 Suppl 1:39-43. doi: 10.2165/00003495-198700341-00010.
This study examined the biliary tract excretion of ofloxacin in 6 post-cholecystectomy patients with a T-tube inserted into the common duct (group A) and 6 patients during cholecystectomy (group B). The patients were given 7 oral doses of ofloxacin 200mg with a 12-hour interval between each dose. Blood and common duct bile samples were collected in group A at various time intervals after the first and the seventh dose. Blood, gallbladder wall, and gallbladder and common duct bile were collected in group B during operation, 6 hours after the seventh dose. Assays were performed by use of high performance liquid chromatography (HPLC). In group A, mean serum Cmax and half-life were 2.6 mg/L and 7.6 hours after the first dose, and 5.3 mg/L and 8 hours after the seventh dose, respectively. Mean common duct bile Cmax and half-life were 6.5 mg/L and 7.5 hours after the first dose, and 12.0 mg/L and 14 hours after the seventh dose, respectively. In group B, mean concentrations (mg/L) were 2.6 in blood, 5.3 in gallbladder wall, 24.6 in gallbladder bile and 10.1 in common duct bile, 6 hours after the seventh dose. These data suggest that ofloxacin may be suitable for the treatment of biliary tract infections.
本研究检测了6例胆总管内置入T形管的胆囊切除术后患者（A组）和6例胆囊切除术患者（B组）中氧氟沙星的胆道排泄情况。患者口服7次氧氟沙星，每次200mg，每次服药间隔12小时。A组在首次和第七次服药后的不同时间间隔采集血液和胆总管胆汁样本。B组在手术期间、第七次服药后6小时采集血液、胆囊壁、胆囊及胆总管胆汁样本。采用高效液相色谱法（HPLC）进行检测。在A组中，首次服药后血清Cmax平均值和半衰期分别为2.6mg/L和7.6小时，第七次服药后分别为5.3mg/L和8小时。首次服药后胆总管胆汁Cmax平均值和半衰期分别为6.5mg/L和7.5小时，第七次服药后分别为12.0mg/L和14小时。在B组中，第七次服药后6小时，血液中的平均浓度（mg/L）为2.6，胆囊壁中为5.3，胆囊胆汁中为24.6，胆总管胆汁中为10.1。这些数据表明氧氟沙星可能适用于治疗胆道感染。
