Couraud L, Fourtillan J B, Saux M C, Bryskier A, Vincent du Laurier M
Thoracic Surgery Unit, Hôpital Xavier Arnozan, Pessac.
Drugs. 1987;34 Suppl 1:37-8. doi: 10.2165/00003495-198700341-00009.
Ofloxacin 200mg twice daily was administered to 17 patients with pulmonary disorders, which necessitated surgery, during the preceding 48 hours and 200mg was administered 1 hour before the operation. During surgery, blood samples and specimens of healthy and diseased lung tissues were taken simultaneously. Ofloxacin levels were determined by HPLC. The mean values of the tissue concentration/plasma concentration ratio were 3.5 +/- 0.4 for the healthy tissue and 3.9 +/- 0.4 for the diseased tissue. These values reflected good penetration of ofloxacin into both healthy and atelectasic pulmonary parenchyma.
在手术前48小时，给17名患有肺部疾病且需要进行手术的患者每日两次服用200毫克氧氟沙星，并在手术前1小时服用200毫克。手术期间，同时采集血样以及健康和患病肺组织的标本。通过高效液相色谱法测定氧氟沙星水平。健康组织的组织浓度/血浆浓度比值的平均值为3.5±0.4，患病组织为3.9±0.4。这些数值反映出氧氟沙星在健康和肺不张的肺实质中均有良好的渗透。
