Department of Neurology, 21767David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Mallinckrodt Institute of Radiology, Division of Neuroradiology, 7548Washington University in St Louis, St Louis, MO, USA.
Am J Alzheimers Dis Other Demen. 2021 Jan-Dec;36:15333175211055325. doi: 10.1177/15333175211055325.
Investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset Alzheimer's Disease (EOAD) with onset <65 years as compared with typical late onset AD (LOAD). To determine whether clinical brain MRI volumes reflect these differences in EOAD compared with LOAD. This study investigated the clinical MRI scans of 45 persons with Clinically Probable AD with onset <65 years, and compared them to 32 with Clinically Probable AD with onset ≥65 years. Brain volumes on their T1 MRI scans were quantified with a volumetric program. Receiver operating curve analyses were performed. Persons with EOAD had significantly smaller parietal lobes (volumetric percentiles) than LOAD. Late onset Alzheimer's Disease had a smaller left putamen and hippocampus. Area Under the Curve was 965% with brain region delineation of EOAD compared to LOAD. This study indicates parietal atrophy less than 30% of normal on clinical MRI scans is suggestive of EOAD compared to LOAD.
研究人员报告称，与典型的晚发性 AD（LOAD）相比，发病年龄<65 岁的早发性 AD（EOAD）患者顶叶 tau 沉积更多，且额顶叶网络受累情况不同。为了确定与 LOAD 相比，临床脑 MRI 体积是否反映了 EOAD 的这些差异。本研究调查了 45 名发病年龄<65 岁的临床可能 AD 患者的临床 MRI 扫描，并将其与 32 名发病年龄≥65 岁的临床可能 AD 患者进行了比较。使用容积程序对 T1 MRI 扫描的脑体积进行了量化。进行了接收者操作特征曲线分析。EOAD 患者的顶叶（容积百分比）明显小于 LOAD。晚发性 AD 的左侧壳核和海马较小。与 LOAD 相比，EOAD 的脑区勾画曲线下面积为 96.5%。本研究表明，与 LOAD 相比，临床 MRI 扫描上顶叶萎缩小于正常的 30%提示 EOAD。
