手握力与认知障碍老年人群中伴有确认淀粉样蛋白负担者的海马和脑叶脑容量相关。
Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.
机构信息
Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.
Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
出版信息
J Alzheimers Dis. 2023;91(3):999-1006. doi: 10.3233/JAD-220886.
BACKGROUND
Strength and mobility are essential for activities of daily living. With aging, weaker handgrip strength, mobility, and asymmetry predict poorer cognition. We therefore sought to quantify the relationship between handgrip metrics and volumes quantified on brain magnetic resonance imaging (MRI).
OBJECTIVE
To model the relationships between handgrip strength, mobility, and MRI volumetry.
METHODS
We selected 38 participants with Alzheimer's disease dementia: biomarker evidence of amyloidosis and impaired cognition. Handgrip strength on dominant and non-dominant hands was measured with a hand dynamometer. Handgrip asymmetry was calculated. Two-minute walk test (2MWT) mobility evaluation was combined with handgrip strength to identify non-frail versus frail persons. Brain MRI volumes were quantified with Neuroreader. Multiple regression adjusting for age, sex, education, handedness, body mass index, and head size modeled handgrip strength, asymmetry and 2MWT with brain volumes. We modeled non-frail versus frail status relationships with brain structures by analysis of covariance.
RESULTS
Higher non-dominant handgrip strength was associated with larger volumes in the hippocampus (p = 0.02). Dominant handgrip strength was related to higher frontal lobe volumes (p = 0.02). Higher 2MWT scores were associated with larger hippocampal (p = 0.04), frontal (p = 0.01), temporal (p = 0.03), parietal (p = 0.009), and occipital lobe (p = 0.005) volumes. Frailty was associated with reduced frontal, temporal, and parietal lobe volumes.
CONCLUSION
Greater handgrip strength and mobility were related to larger hippocampal and lobar brain volumes. Interventions focused on improving handgrip strength and mobility may seek to include quantified brain volumes on MR imaging as endpoints.
背景
力量和灵活性是日常生活活动的基础。随着年龄的增长，手部握力较弱、移动能力较差和不对称性会预测认知能力较差。因此，我们试图量化手部握力指标与脑磁共振成像（MRI）体积之间的关系。
目的
建立手部握力、移动能力和 MRI 体素定量之间的关系模型。
方法
我们选择了 38 名患有阿尔茨海默病痴呆症的参与者：有淀粉样蛋白和认知障碍的生物标志物证据。使用手持测力计测量优势手和非优势手的握力。计算握力的不对称性。两分钟步行测试（2MWT）的移动能力评估与握力相结合，以识别非虚弱与虚弱的人。使用 Neuroreader 对脑 MRI 体积进行定量。多元回归模型调整年龄、性别、教育程度、利手、体重指数和头围，将握力、不对称性和 2MWT 与脑体积联系起来。我们通过协方差分析模型来分析非虚弱与虚弱状态与脑结构之间的关系。
结果
非优势手的握力越高，与海马体体积越大（p=0.02）相关。优势手的握力与额叶体积较大相关（p=0.02）。较高的 2MWT 分数与海马体（p=0.04）、额叶（p=0.01）、颞叶（p=0.03）、顶叶（p=0.009）和枕叶（p=0.005）体积较大相关。虚弱与额叶、颞叶和顶叶体积减少相关。
结论
较大的握力和移动能力与较大的海马体和脑叶体积相关。以提高握力和移动能力为重点的干预措施可能会将 MRI 上的脑体积定量作为终点。
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