使用 TSPO 配体 [C]-PK11195，慢性疲劳综合征或 Q 热疲劳综合征女性患者没有神经炎症迹象。
No Signs of Neuroinflammation in Women With Chronic Fatigue Syndrome or Q Fever Fatigue Syndrome Using the TSPO Ligand [C]-PK11195.
机构信息
From the Radboud Expertise Center for Q Fever (R.R., S.K., L.J., M.N., J.M., C.B.-R.), Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center; Department of Internal Medicine (R.R., M.R., S.K., L.J., M.N., J.M., C.B.-R.), Radboud University Medical Center, Nijmegen; Department of Medical Psychology (H. Knoop), Amsterdam University Medical Centers, Amsterdam Public Health Research Institute, University of Amsterdam; Department of Psychiatry (H. Klein), University of Groningen, University Medical Center Groningen; and Department of Nuclear Medicine and Molecular Imaging (J.D.), University of Groningen, University Medical Center Groningen, the Netherlands.
出版信息
Neurol Neuroimmunol Neuroinflamm. 2021 Nov 23;9(1). doi: 10.1212/NXI.0000000000001113. Print 2022 Jan.
BACKGROUND AND OBJECTIVES
The pathophysiology of chronic fatigue syndrome (CFS) and Q fever fatigue syndrome (QFS) remains elusive. Recent data suggest a role for neuroinflammation as defined by increased expression of translocator protein (TSPO). In the present study, we investigated whether there are signs of neuroinflammation in female patients with CFS and QFS compared with healthy women, using PET with the TSPO ligand C-()-(2-chlorophenyl)--methyl--(1-methylpropyl)-3-isoquinoline-carbox-amide ([C]-PK11195).
METHODS
The study population consisted of patients with CFS (n = 9), patients with QFS (n = 10), and healthy subjects (HSs) (n = 9). All subjects were women, matched for age (±5 years) and neighborhood, aged between 18 and 59 years, who did not use any medication other than paracetamol or oral contraceptives, and were not vaccinated in the last 6 months. None of the subjects reported substance abuse in the past 3 months or reported signs of underlying psychiatric disease on the Mini-International Neuropsychiatric Interview. All subjects underwent a [C]-PK11195 PET scan, and the [C]-PK11195 binding potential (BP) was calculated.
RESULTS
No statistically significant differences in BP were found for patients with CFS or patients with QFS compared with HSs. BP of [C]-PK11195 correlated with symptom severity scores in patients with QFS, but a negative correlation was found in patients with CFS.
DISCUSSION
In contrast to what was previously reported for CFS, we found no significant difference in BP of [C]-PK11195 when comparing patients with CFS or QFS with healthy neighborhood controls. In this small series, we were unable to find signs of neuroinflammation in patients with CFS and QFS.
TRIAL REGISTRATION INFORMATION
EudraCT number 2014-004448-37.
背景与目的
慢性疲劳综合征（CFS）和 Q 热疲劳综合征（QFS）的病理生理学仍不明确。最近的数据表明，神经炎症作为一个定义，其表现为转位蛋白（TSPO）表达增加。在本研究中，我们使用 TSPO 配体 C-（）-（2-氯苯基）-甲基--（1-甲基丙基）-3-异喹啉-羧酰胺（[C]-PK11195）的正电子发射断层扫描（PET），研究与健康女性相比，女性 CFS 和 QFS 患者是否存在神经炎症迹象。
方法
研究人群包括 CFS 患者（n=9）、QFS 患者（n=10）和健康受试者（HSs）（n=9）。所有受试者均为女性，年龄（±5 岁）和居住地点相匹配，年龄在 18 至 59 岁之间，除了扑热息痛或口服避孕药外，未使用任何其他药物，且在过去 6 个月内未接种疫苗。所有受试者在过去 3 个月内均未报告药物滥用，且在 Mini-国际神经精神访谈中未报告有潜在精神疾病的迹象。所有受试者均进行了 [C]-PK11195 PET 扫描，并计算了 [C]-PK11195 结合潜能（BP）。
结果
与 HSs 相比，CFS 患者或 QFS 患者的 BP 无统计学差异。QFS 患者的 BP 与症状严重程度评分相关，但 CFS 患者呈负相关。
讨论
与之前报道的 CFS 相反，我们在比较 CFS 或 QFS 患者与健康对照组时，未发现 [C]-PK11195 的 BP 有显著差异。在这个小系列中，我们无法在 CFS 和 QFS 患者中发现神经炎症的迹象。
试验注册信息
EudraCT 编号 2014-004448-37。
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