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Two-faced behavior of microglia in Alzheimer's disease.

作者信息

Chen Yun, Colonna Marco

机构信息

Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO, USA.

Department of Neurology, Washington University School of Medicine in St Louis, St Louis, MO, USA.

出版信息

Nat Neurosci. 2022 Jan;25(1):3-4. doi: 10.1038/s41593-021-00963-w.

DOI:10.1038/s41593-021-00963-w
PMID:34815557
Abstract
摘要

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本文引用的文献

1
Microglia contribute to the propagation of Aβ into unaffected brain tissue.小胶质细胞有助于 Aβ 向未受影响的脑组织扩散。
Nat Neurosci. 2022 Jan;25(1):20-25. doi: 10.1038/s41593-021-00951-0. Epub 2021 Nov 22.
用于双管齐下调节阿尔茨海默病中慢性激活的小胶质细胞介导的神经炎症的增强血脑屏障穿透和小胶质细胞靶向纳米调节剂。
Acta Pharm Sin B. 2025 Feb;15(2):1098-1111. doi: 10.1016/j.apsb.2025.01.015. Epub 2025 Jan 25.
4
25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer's disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition.25-羟基胆固醇调节小胶质细胞功能并加剧阿尔茨海默病病理：胆固醇酯化抑制的机制见解和治疗潜力
J Neuroinflammation. 2025 Feb 25;22(1):50. doi: 10.1186/s12974-025-03357-y.
5
Nebulized seabuckthorn seed oil inhalation attenuates Alzheimer's disease progression in APP/PS1 mice.雾化沙棘籽油吸入可减缓APP/PS1小鼠的阿尔茨海默病进展。
Sci Rep. 2025 Feb 21;15(1):6368. doi: 10.1038/s41598-025-89747-x.
6
7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer's disease.7-酮胆固醇导致阿尔茨海默病中由小胶质细胞驱动的星形胶质细胞活性氧增加。
bioRxiv. 2025 Jan 28:2025.01.19.633810. doi: 10.1101/2025.01.19.633810.
7
CD4-Derived Double-Negative T Cells Ameliorate Alzheimer's Disease-Like Phenotypes in the 5×FAD Mouse Model.CD4衍生的双阴性T细胞改善5×FAD小鼠模型中的阿尔茨海默病样表型。
CNS Neurosci Ther. 2025 Jan;31(1):e70187. doi: 10.1111/cns.70187.
8
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease.衰老和阿尔茨海默病中人类小胶质细胞和脑周血管巨噬细胞的可塑性
medRxiv. 2024 Dec 5:2023.10.25.23297558. doi: 10.1101/2023.10.25.23297558.
9
Simple and highly specific targeting of resident microglia with adeno-associated virus.利用腺相关病毒对常驻小胶质细胞进行简单且高度特异性的靶向
iScience. 2024 Aug 12;27(9):110706. doi: 10.1016/j.isci.2024.110706. eCollection 2024 Sep 20.
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Microfluidic Wound-Healing Assay for Comparative Study on Fluid Dynamic, Chemical and Mechanical Wounding on Microglia BV2 Migration.用于比较研究流体动力学、化学和机械损伤对小胶质细胞BV2迁移影响的微流控伤口愈合分析
Micromachines (Basel). 2024 Aug 2;15(8):1004. doi: 10.3390/mi15081004.