Liu Weicong, Yan Qianwen, Xia Chen, Wang Xiaoxiong, Kumar Abhinav, Wang Yan, Liu Yiwei, Pan Ying, Liu Jianqiang
Department of Pharmacy, The First People's Hospital of Foshan (Affiliated FoShan Hospital of Sun Yat-sen University), Foshan 528000, China.
Department of Pathology, The First People's Hospital of Foshan, Foshan 528000, China.
J Mater Chem B. 2021 Jun 2;9(22):4459-4474. doi: 10.1039/d1tb00453k.
In improving the tumor-targeting ability of metal-organic frameworks (MOFs) for tumor therapy and avoiding the clearance as well as capture by the immune system, there are still several challenges, which limit the development and bio-applications of MOFs. To overcome these challenges, various targeted modification strategies have been proposed. Amongst all the strategies, a promising cell membrane coating method has been explored and utilized for the syntheses of new cell membrane biomimetic MOFs (CMMs). Through such coating, various source cell membranes (e.g., red blood cell, immune cell, cancer cell, platelet, and fusion cell membranes) can be endowed with excellent properties such as long blood circulation, immune escape, and targeting ability. In the presented perspective, the synthetic method, characterization, and research progress in tumor therapy based on CMMs have been summarized. This is because, like many other technologies, the cell membrane coating technology also has several challenges to overcome. Hence, addressing and overcoming such challenges will promote and extend the bio-applications of MOFs which in the future may become a prospective carrier for cancer nano-medicine. Finally, the prospects and challenges of utilizing CMMs for tumor therapy have been discussed.
在提高金属有机框架（MOFs）用于肿瘤治疗的肿瘤靶向能力以及避免被免疫系统清除和捕获方面，仍然存在若干挑战，这些挑战限制了MOFs的发展和生物应用。为了克服这些挑战，人们提出了各种靶向修饰策略。在所有策略中，一种有前景的细胞膜包覆方法已被探索并用于合成新型细胞膜仿生MOFs（CMMs）。通过这种包覆，各种来源的细胞膜（如红细胞膜、免疫细胞膜、癌细胞膜、血小板膜和融合细胞膜）可被赋予诸如长循环时间、免疫逃逸和靶向能力等优异特性。在本综述中，总结了基于CMMs的肿瘤治疗的合成方法、表征及研究进展。这是因为，与许多其他技术一样，细胞膜包覆技术也有若干挑战需要克服。因此，解决和克服这些挑战将促进和扩展MOFs的生物应用，MOFs未来可能成为癌症纳米医学的一种有前景的载体。最后，讨论了利用CMMs进行肿瘤治疗的前景和挑战。
