Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Clinical Research Development Unit (CRDU), Golestan University of Medical Sciences, Gorgan, Iran.
Arch Iran Med. 2021 Oct 1;24(10):727-732. doi: 10.34172/aim.2021.107.
Liver cancer (LC) is among the most common and fatal cancers worldwide. A four-fold increasing trend is reported for LC age-standardized mortality rate (ASMR) in Iran within 1990-2015. In the present study, we aimed to report the incidence rate of LC during the 13-year establishment of the Golestan population-based cancer registry (GPCR).
Age-standardized incidence rate (ASIR) per 100000 person-years was calculated using CanReg5 software. The Joint point regression analysis was used to assess the temporal trends in incidence rate of LC.
During the study period, GPCR registered 575 of LC cases, of which 373 (64.9%) were men and 297 (51.6%) lived in rural areas. The mean (SD) age of LC in men and women were 60.3 (17.2) and 58.0 (17.1), respectively. The ASIR of LC was significantly higher in men than women (4.7 vs. 2.6; value<0.01) and a minimal increasing trend in LC incidence was observed in both sexes. The incidence rate of LC was significantly higher in rural areas compared to the urbans (3.91 vs. 3.40; value=0.04). In the last 13 years, rural population had a significant increasing trend in ASIR of LC (average annual percent change [AAPC]=7.85, value=0.005).
LC was more prevalent in men among both urban and rural populations. The results showed a significant increasing trend in rural areas that requires Golestan health care system to take action in controlling the burden of LC in rural areas.
肝癌（LC）是全球最常见和最致命的癌症之一。在 1990 年至 2015 年期间，伊朗 LC 的年龄标准化死亡率（ASMR）报告显示呈四倍增长趋势。在本研究中，我们旨在报告戈勒斯坦基于人群的癌症登记处（GPCR）建立 13 年来 LC 的发病率。
使用 CanReg5 软件计算每 100000 人年的年龄标准化发病率（ASIR）。联合点回归分析用于评估 LC 发病率的时间趋势。
在研究期间，GPCR 登记了 575 例 LC 病例，其中 373 例（64.9%）为男性，297 例（51.6%）居住在农村地区。男性和女性 LC 的平均（SD）年龄分别为 60.3（17.2）和 58.0（17.1）。男性 LC 的 ASIR 明显高于女性（4.7 比 2.6； 值<0.01），并且观察到两性的 LC 发病率呈轻微上升趋势。农村地区 LC 的发病率明显高于城市（3.91 比 3.40； 值=0.04）。在过去的 13 年中，农村人口的 LC 的 ASIR 呈显著上升趋势（平均年度百分比变化 [AAPC]=7.85， 值=0.005）。
LC 在城乡男性中更为普遍。结果表明农村地区呈显著上升趋势，需要戈勒斯坦医疗保健系统采取行动控制农村地区 LC 的负担。
