Zhong Danni, Zhang Dongxiao, Chen Wei, He Jian, Ren Chaojie, Zhang Xingcai, Kong Na, Tao Wei, Zhou Min
Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Institute of Translational Medicine, Zhejiang University, Hangzhou, China.
Sci Adv. 2021 Nov 26;7(48):eabi9265. doi: 10.1126/sciadv.abi9265. Epub 2021 Nov 24.
Design of innovative strategies for oral drug delivery is particularly promising for intestinal disease treatment. However, many obstacles such as poor therapeutic efficacy and low bioavailability and biocompatibility remain to be addressed. Here, we report a versatile formulation based on a helical-shaped cyanobacterium, (SP), loaded with curcumin (SP@Curcumin) for the treatment of colon cancer and colitis, two types of intestinal diseases. In radiotherapy for colon cancer, SP@Curcumin could mediate combined chemo- and radiotherapy to inhibit tumor progression while acting as a radioprotector to scavenge reactive oxygen species induced by the high dose of x-ray radiation in healthy tissues. SP@Curcumin could also reduce the production of proinflammatory cytokines and thereby exerted anti-inflammatory effects against colitis. The oral drug delivery system not only leveraged the biological properties of microalgal carriers to improve the bioavailability of loaded drugs but also performed excellent antitumor and anti-inflammation efficacy for intestinal disease treatment.
设计用于口服给药的创新策略对于肠道疾病治疗特别有前景。然而，许多障碍，如治疗效果差、生物利用度低以及生物相容性问题仍有待解决。在此，我们报告了一种基于螺旋形蓝藻（SP）负载姜黄素（SP@姜黄素）的多功能制剂，用于治疗两种肠道疾病——结肠癌和结肠炎。在结肠癌的放射治疗中，SP@姜黄素可以介导化疗和放疗联合作用以抑制肿瘤进展，同时作为辐射防护剂清除健康组织中高剂量X射线辐射诱导产生的活性氧。SP@姜黄素还可以减少促炎细胞因子的产生，从而对结肠炎发挥抗炎作用。该口服给药系统不仅利用了微藻载体的生物学特性来提高负载药物的生物利用度，而且在肠道疾病治疗中表现出优异的抗肿瘤和抗炎功效。
