Health Sciences Department, Franklin Pierce University, Rindge, NH, USA.
School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
J Sports Sci. 2022 Mar;40(6):614-620. doi: 10.1080/02640414.2021.2009163. Epub 2021 Nov 25.
There is no clear evidence for the best time of day for physical activity in benefitting health among individuals with type 2 diabetes. This study was aimed to examine whether there is an optimal time of day for physical activity to increase longevity. In this cohort study of 904 patients with type 2 diabetes, we fitted a Cox model with restricted cubic spline to examine the association of moderate-to-vigorous physical activity (MVPA) and time of day with all-cause mortality. Compositional data analysis was used to examine the association of time spent in sedentary behaviour (SB), light-intensity physical activity (LIPA), morning MVPA, and evening MVPA with all-cause mortality. MVPA was inversely associated with all-cause mortality in a curvilinear manner (P-value for nonlinearity<0.0001). The interaction between MVPA and time of day was not significant (P-value for interaction=0.11). Substituting evening MVPA with morning MVPA was not associated with appreciable changes in all-cause mortality. There is no evidence that the time of day moderates the association of MVPA with all-cause mortality. Patients with higher levels of MVPA had lower mortality regardless of the timing of MVPA. Patients with type 2 diabetes should engage in regular physical activity whenever possible.
目前尚无明确证据表明，对于 2 型糖尿病患者而言，一天中何时进行体力活动最有益于健康。本研究旨在探讨体力活动是否存在最佳时间以延长寿命。在这项纳入 904 例 2 型糖尿病患者的队列研究中，我们采用受限立方样条 Cox 模型来检验中等到剧烈体力活动（MVPA）与时间与全因死亡率之间的关系。我们采用组成数据分析来检验久坐行为（SB）、低强度体力活动（LIPA）、上午 MVPA 和傍晚 MVPA 与全因死亡率之间的关系。MVPA 与全因死亡率呈曲线相关（非线性 P 值<0.0001）。MVPA 与时间之间的交互作用不显著（交互作用 P 值=0.11）。用早晨 MVPA 替代傍晚 MVPA 与全因死亡率无明显变化相关。目前尚无证据表明，时间会调节 MVPA 与全因死亡率之间的关联。无论 MVPA 的时间如何，MVPA 水平较高的患者死亡率均较低。2 型糖尿病患者应尽可能定期进行体力活动。
