Institute of Sport Exercise & Health, Division of Surgery & Interventional Science, University College London, 170 Tottenham Court Road, W1T 7HA London, UK.
Institute of Sport Exercise & Health, Division of Surgery & Interventional Science, University College London, 170 Tottenham Court Road, W1T 7HA London, UK.
J Affect Disord. 2023 Jan 1;320:616-620. doi: 10.1016/j.jad.2022.09.110. Epub 2022 Sep 30.
The benefits of moderate to vigorous physical activity(MVPA) in lowering depression risk are well established, but there is mixed evidence on sleep, sedentary behaviour(SB), and light-intensity physical activity(LIPA). These behaviours are often considered in isolation, neglecting their behavioural and biological interdependences. We investigated how time spent in one behaviour relative to others was associated with depression risk.
We included 4738 individuals from the 1970 British Cohort study (age 46 wave). Depression status was ascertained using self-reported doctor visits and prescribed anti-depressant use. MVPA, LIPA, SB and sleep were ascertained using thigh-worn accelerometers worn consecutively for 7 days. Compositional logistic regression was used to examine associations between different compositions of time spent in movement behaviours and depression.
More time spent in MVPA, relative to SB, sleep or LIPA, was associated with a lower risk of depression. When modelling reallocation of time (e.g. replacing time in one behaviour with another), replacing sleep, SB or LIPA with MVPA time was strongly associated with lower depression risk. Reallocating time between SB, sleep or LIPA had minimal to no effect.
Data was cross-sectional, therefore causality cannot be inferred. Accelerometers do not capture SB context (e.g. TV watching, reading) nor separate biological sleep from time spent in bed.
Displacing any behaviour with MVPA was associated with a lower risk of depression. This study provides promising support that increasing MVPA, even in small doses, can have a positive impact on prevention, mitigation and treatment of depression.
中等至剧烈强度体力活动（MVPA）有益于降低抑郁风险，这一点已得到充分证实，但关于睡眠、久坐行为（SB）和低强度体力活动（LIPA）的证据存在差异。这些行为通常是孤立考虑的，忽略了它们的行为和生物学上的相互依存关系。我们研究了相对于其他行为，一个行为的时间分配与抑郁风险的关系。
我们纳入了来自 1970 年英国队列研究（年龄 46 波）的 4738 名个体。抑郁状况通过自我报告的就诊次数和开处方的抗抑郁药使用情况来确定。MVPA、LIPA、SB 和睡眠通过连续佩戴在大腿上的加速度计连续 7 天进行测量。使用组合逻辑回归来检验不同运动行为时间分配与抑郁之间的关系。
与 SB、睡眠或 LIPA 相比，MVPA 时间分配越多，抑郁风险越低。当对时间重新分配（例如，用一种行为的时间替换另一种行为的时间）进行建模时，用 MVPA 时间替换睡眠、SB 或 LIPA 时间与较低的抑郁风险密切相关。在 SB、睡眠或 LIPA 之间重新分配时间几乎没有影响。
数据是横断面的，因此不能推断因果关系。加速度计无法捕捉 SB 环境（例如看电视、阅读），也无法将生物睡眠时间与在床上度过的时间区分开来。
用 MVPA 替代任何行为都与较低的抑郁风险相关。这项研究为增加 MVPA，即使是小剂量，也能对预防、缓解和治疗抑郁产生积极影响提供了有希望的支持。
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