Zhang Liang, Chen Shuaiyin, Zhang Weiguo, Yang Haiyan, Jin Yuefei, Duan Guangcai
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.
Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
Front Microbiol. 2021 Nov 8;12:770935. doi: 10.3389/fmicb.2021.770935. eCollection 2021.
Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic since March 2020 and led to significant challenges to over 200 countries and regions all over the world. The establishment of highly pathogenic coronavirus animal model is beneficial for the study of vaccines and pathogenic mechanism of the virus. Laboratory mice, Syrian hamsters, Non-human primates and Ferrets have been used to establish animal models of emerging coronavirus infection. Different animal models can reproduce clinical infection symptoms at different levels. Appropriate animal models are of great significance for the pathogenesis of COVID-19 and the research progress related to vaccines. This review aims to introduce the current progress about experimental animal models for SARS-CoV-2, and collectively generalize critical aspects of disease manifestation in humans and increase their usefulness in research into COVID-19 pathogenesis and developing new preventions and treatments.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）自2020年3月以来已成为全球大流行疾病，并给全球200多个国家和地区带来了重大挑战。建立高致病性冠状病毒动物模型有利于研究病毒的疫苗和致病机制。实验室小鼠、叙利亚仓鼠、非人灵长类动物和雪貂已被用于建立新型冠状病毒感染的动物模型。不同的动物模型能在不同程度上重现临床感染症状。合适的动物模型对于COVID-19的发病机制及疫苗相关研究进展具有重要意义。本综述旨在介绍目前关于SARS-CoV-2实验动物模型的进展，并总结人类疾病表现的关键方面，提高其在COVID-19发病机制研究以及开发新的预防和治疗方法中的实用性。
