微生物组、胃肠道癌症和免疫疗法。
The microbiome, gastrointestinal cancer, and immunotherapy.
机构信息
Department of Medicine, University of Florida, Gainesville, Florida, USA.
Department of Infectious Diseases and Immunology, University of Florida, Gainesville, Florida, USA.
出版信息
J Gastroenterol Hepatol. 2022 Feb;37(2):263-272. doi: 10.1111/jgh.15742. Epub 2021 Dec 3.
Abstract
The gastrointestinal tract greatly contributes to global cancer burden and cancer-related deaths. The microbiota represents the population of microorganisms that live in and around the body, located primarily in the gastrointestinal tract. The microbiota has been implicated in colorectal cancer development and progression, but its role in cancer therapy for the gastrointestinal tract is less defined, especially for extra-intestinal cancers. In this review, we discuss the past 5 years of research into microbial involvement in immune-related therapies for colorectal, pancreatic, hepatic, and gastric cancers, with the goal of highlighting recent advances and new areas for investigation in this field.
摘要
胃肠道在全球癌症负担和癌症相关死亡中起着重要作用。微生物组代表了生活在体内和周围的微生物群体，主要位于胃肠道中。微生物组已被牵连到结直肠癌的发展和进展中，但它在胃肠道癌症治疗中的作用尚未确定，特别是对于肠外癌症。在这篇综述中，我们讨论了过去 5 年关于微生物参与免疫相关疗法治疗结直肠癌、胰腺癌、肝癌和胃癌的研究，旨在强调该领域的最新进展和新的研究领域。
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