Ahn Hyeok, Min Kyungchan, Lee Eulgi, Kim Hyun, Kim Sujeong, Kim Yunjae, Kim Gihyeon, Cho Beomki, Jeong Chanyeong, Kim Yeongmin, Park Hansoo
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
Microorganisms. 2022 Sep 23;10(10):1896. doi: 10.3390/microorganisms10101896.
Remarkable progress has occurred over the past two decades in identifying microbiomes affecting the human body in numerous ways. The microbiome is linked to gastrointestinal (GI) tract cancer. The purpose of this study was to determine if there is a common microbiome among GI tract cancers and how the microbiome affects the disease. To ensure ethnic consistency, Korean patients with GI tract cancer were selected. is an enriched bacteria in all cancer tissues. is a Gram-negative obligate anaerobe that promotes colorectal cancer. Through Gene Set Enrichment Analysis (GSEA) and Differentially Expressed Genes (DEG) analyses, the upregulation of the G2M checkpoint pathway was identified in the -high group. Cell viability and G2M checkpoint pathway genes were examined in MC 38 cells treated with . upregulated the expression of G2M checkpoint pathway genes and the cell proliferation of MC 38 cells. facilitated cancer's use of G2M checkpoint pathways and could be a therapeutic target in Korean GI tract cancer.
在过去二十年里，在识别以多种方式影响人体的微生物群方面取得了显著进展。微生物群与胃肠道（GI）癌症有关。本研究的目的是确定胃肠道癌症之间是否存在共同的微生物群，以及微生物群如何影响该疾病。为确保种族一致性，选择了韩国胃肠道癌症患者。 是所有癌症组织中富集的细菌。 是一种促进结直肠癌的革兰氏阴性专性厌氧菌。通过基因集富集分析（GSEA）和差异表达基因（DEG）分析，在 -高组中发现了G2M检查点通路的上调。在用 处理的MC 38细胞中检测了细胞活力和G2M检查点通路基因。 上调了G2M检查点通路基因的表达和MC 38细胞的细胞增殖。 促进了癌症对G2M检查点通路的利用，并且 可能是韩国胃肠道癌症的一个治疗靶点。
