果皮的亲水性提取物可预防苯肼诱导的肝毒性和溶血性贫血。
Hydrophilic extract of pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia.
作者信息
Amin Fatemeh, Parvaz Najmeh, Askari Nahid, Khademalhosseini Morteza, Khanamani Falahatipour Sakineh, Fatemi Iman, Khajehasani Fatemeh, Taghipour Zahra, Khanamani Falahati-Pour Soudeh
机构信息
Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
Avicenna J Phytomed. 2024 May-Jun;14(3):375-387. doi: 10.22038/AJP.2024.23925.
OBJECTIVE
is commonly used in traditional medicine to treat various disorders. This study aims to investigate the anti-anemia and hepatoprotective effects of pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia.
MATERIALS AND METHODS
PVPE was prepared using the maceration method. The extract was administered at doses of 20, 80, and 160 mg/kg for 28 days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood.
RESULTS
Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects.
CONCLUSION
PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.
目的
在传统医学中常用于治疗各种疾病。本研究旨在探讨番石榴果皮提取物（PVPE）对苯肼（PHZ）诱导的大鼠贫血模型的抗贫血和肝保护作用。
材料与方法
采用浸渍法制备PVPE。将提取物以20、80和160mg/kg的剂量给予正常大鼠和经PHZ处理的大鼠，持续28天。通过肝脏和血液中生化、组织学、血液学和分子生物标志物的变化来评估PVPE的作用。
结果
与贫血组相比，给贫血动物施用PVPE可显著恢复对血液学参数的这些有害影响。在贫血大鼠的肝脏组织中可见库普弗细胞活化。施用PVPE减轻了这些有害影响。
结论
PVPE具有强大的抗氧化活性，可能是临床环境中治疗贫血和肝脏保护的一种有前景的疗法。
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