State Key Laboratory of Metastable Materials Science & Technology, Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China.
School of Computer and Communication Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China.
Biosensors (Basel). 2021 Oct 30;11(11):430. doi: 10.3390/bios11110430.
A compact microfluidic Raman detection system based on a single-ring negative-curvature hollow-core fiber is presented. The system can be used for in-line qualitative and quantitative analysis of biochemicals. Both efficient light coupling and continuous liquid injection into the hollow-core fiber were achieved by creating a small gap between a solid-core fiber and the hollow-core fiber, which were fixed within a low-cost ceramic ferrule. A coupling efficiency of over 50% from free-space excitation laser to the hollow core fiber was obtained through a 350 μm-long solid-core fiber. For proof-of-concept demonstration of bioprocessing monitoring, a series of ethanol and glucose aqueous solutions at different concentrations were used. The limit of detection achieved for the ethanol solutions with our system was ~0.04 vol.% (0.32 g/L). Such an all-fiber microfluidic device is robust, provides Raman measurements with high repeatability and reusability, and is particularly suitable for the in-line monitoring of bioprocesses.
提出了一种基于单环负曲率空芯光纤的紧凑型微流控拉曼检测系统。该系统可用于生化物质的在线定性和定量分析。通过在实心光纤和空心光纤之间创建一个小间隙，并将其固定在低成本的陶瓷套管内，实现了高效的光耦合和连续的液体注入到空心光纤中。通过 350μm 长的实心光纤，从自由空间激发激光到空心光纤的耦合效率超过 50%。为了演示生物加工监测的概念验证，使用了一系列不同浓度的乙醇和葡萄糖水溶液。我们的系统对乙醇溶液的检测限约为 0.04 体积%（0.32g/L）。这种全光纤微流控装置具有很强的鲁棒性，提供具有高重复性和可重复性的拉曼测量，特别适合生物过程的在线监测。
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