Jones John G
CNC-Center for Neuroscience and Cell Biology, CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.
Metabolites. 2021 Oct 29;11(11):751. doi: 10.3390/metabo11110751.
The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.
肝脏是全身营养和燃料代谢的关键节点，也是外源性化合物解毒的主要场所。因此，肝脏代谢物浓度和/或周转率反映了肝脏和全身代谢疾病的状况以及药物的处置情况。作为一种在这些情况下更好地理解肝脏代谢的工具，体内磁共振波谱（MRS）提供了一种非侵入性手段，可通过直接观察特定代谢物的浓度和动态以及观察其被稳定同位素示踪剂富集的情况来实时监测肝脏代谢活动。本综述总结了过去35年中体内MRS在人体肝脏代谢研究中的应用和进展，并讨论了超高场磁共振系统和超极化稳定同位素示踪剂的发展将带来的未来方向和机遇。
