Medical Research, R&D Healthcare Division, Emami Ltd, 13, BT Road, Belgharia, 700056 Kolkata, India; Department of Pharmacy, Birla Institute of Technology and Science, Pilani (BITS-PILANI), Pilani Campus, Rajasthan, India.
Department of Pharmacy, Birla Institute of Technology and Science, Pilani (BITS-PILANI), Pilani Campus, Rajasthan, India.
Int J Biol Macromol. 2022 Jan 1;194:521-538. doi: 10.1016/j.ijbiomac.2021.11.095. Epub 2021 Nov 22.
As per the WHO, every year around 2.1 million women are detected with breast cancer. It is one of the most invasive cancer in women and second most among all, contributing around 15% of death worldwide. The available anticancer therapies including chemo, radio, and hormone therapy are associated with a high load of reversible and irreversible adverse effects, limited therapeutic efficacy, and low chances of quality survival. To minimize the side effects, improving therapeutic potency and patient compliance promising targeted therapies are highly desirable. In this sequence, various nanocarriers and target modified systems have been explored by researchers throughout the world. Among these chitosan-based nanocarriers offers one of the most interesting, flexible, and biocompatible systems. The unique characteristics of chitosan like surface flexibility, biocompatibility, hydrophilicity, non-toxic and cost-effective behavior assist to overcome the inadequacy of existing therapy. The present review throws light on the successes, failures, and current status of chitosan modified novel techniques for tumor targeting of bioactives. It also emphasizes the molecular classification of breast cancer and current clinical development of novel therapies. The review compiles most relevant works of the past 10 years focusing on the application of chitosan-based nanocarrier against breast cancer.
根据世界卫生组织的数据，每年约有 210 万名女性被诊断出患有乳腺癌。它是女性中最具侵袭性的癌症之一，也是全球第二大致死癌症，约占全球死亡人数的 15%。现有的抗癌疗法包括化疗、放疗和激素治疗，这些疗法都与高可逆和不可逆的副作用、有限的治疗效果以及低质量生存机会有关。为了最大限度地减少副作用，提高治疗效果和患者依从性，人们非常希望采用有前途的靶向治疗方法。在这种情况下，世界各地的研究人员都在探索各种纳米载体和靶向修饰系统。在这些基于壳聚糖的纳米载体中，壳聚糖提供了最有趣、最灵活和最具生物相容性的系统之一。壳聚糖独特的特性，如表面灵活性、生物相容性、亲水性、无毒性和成本效益，有助于克服现有治疗方法的不足。本综述重点介绍了壳聚糖修饰的新型技术在生物活性物质肿瘤靶向方面的成功、失败和现状。它还强调了乳腺癌的分子分类和新型治疗方法的当前临床进展。本综述汇集了过去 10 年中最相关的工作，重点介绍了基于壳聚糖的纳米载体在治疗乳腺癌方面的应用。
