School of Materials Science and Engineering, Xihua University, No. 999, Jinzhou Road, Jinniu District, Chengdu, Sichuan Province 610039, China.
Institute of Burn Research, Southwest Hospital & State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Int J Biol Macromol. 2022 Jan 1;194:644-653. doi: 10.1016/j.ijbiomac.2021.11.108. Epub 2021 Nov 22.
The healing of defected skin tissue is a complex process, especially for chronic wounds. Poor healing of these wounds may cause extensive suffering and high cost for patients. Traditional wound dressings are typically designed for a single function and they cannot satisfy all requirements for the whole process of wound healing. Therefore, it is necessary to develop new types of wound dressings with multiple functions for wound healing. In particular, adding an antibacterial function has been shown to be of great benefit during tissue repair. Nano‑silver is widely used in wound treatment because of various advantages, such as its wide antibacterial spectrum and lower drug resistance. Therefore, wound dressings loaded with nano‑silver have attracted widespread attention in wound healing. Naturally derived polysaccharides hold great potential as wound dressings, because of their abundant availability, low prices and good biocompatibility. In this review, nano‑silver functionalized polysaccharide-based wound dressings are systematically reviewed, including their preparation methods, antibacterial performances and classification of nano‑silver wound dressings. Moreover, the toxicity of nano‑silver based wound dressings is discussed and the prospective research direction is elaborated. This review aims to provide readers with an overview of the latest developments in silver nanotechnology, and to provide a little guidance for the research of nano‑silver functionalized polysaccharide-based wound dressings.
缺陷皮肤组织的愈合是一个复杂的过程,特别是对于慢性伤口。这些伤口愈合不良可能会给患者带来广泛的痛苦和高昂的成本。传统的伤口敷料通常设计为单一功能,它们不能满足伤口愈合全过程的所有要求。因此,有必要开发具有多种功能的新型伤口敷料来进行伤口愈合。特别是,在组织修复过程中添加抗菌功能已被证明是非常有益的。由于纳米银具有广谱抗菌和较低的耐药性等优点,因此被广泛应用于伤口处理。因此,负载纳米银的伤口敷料在伤口愈合方面引起了广泛关注。天然衍生的多糖作为伤口敷料具有很大的潜力,因为它们具有丰富的可用性、低廉的价格和良好的生物相容性。本综述系统地综述了纳米银功能化多糖基伤口敷料,包括其制备方法、抗菌性能和纳米银伤口敷料的分类。此外,还讨论了纳米银基伤口敷料的毒性,并阐述了前瞻性的研究方向。本综述旨在为读者提供纳米银技术最新发展的概述,并为纳米银功能化多糖基伤口敷料的研究提供一些指导。
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