Ge Hengwei, Wang Yizhe, Zhao Xihong
Research Center for Environmental Ecology and Engineering, Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Research Center for Environmental Ecology and Engineering, Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Microb Pathog. 2022 Jan;162:105306. doi: 10.1016/j.micpath.2021.105306. Epub 2021 Nov 22.
Foodborne diseases caused by foodborne pathogens are one of the main problems threatening human health and safety. The emergence of multi-drug resistant strains due to the abuse of antibiotics has increased the difficulty of clinical treatment. Research on the drug resistance mechanism of foodborne pathogens has become an effective method to solve multi-drug resistant strains. In this paper, the four main drug resistance mechanisms, including reduced cell membrane permeability, efflux pump mechanism, target site mutation mechanism, and enzymatic hydrolysis, were used to systematically analyze the drug resistance of Salmonella, Listeria monocytogenes, and Escherichia coli. And the new methods were discussed that may be used to solve the drug resistance of foodborne pathogens such as CRISPR and bacteriophages. This review provided a certain theoretical basis for the treatment of foodborne diseases.
食源性病原体引起的食源性疾病是威胁人类健康与安全的主要问题之一。抗生素滥用导致的多重耐药菌株的出现增加了临床治疗的难度。对食源性病原体耐药机制的研究已成为解决多重耐药菌株的有效方法。本文利用细胞膜通透性降低、外排泵机制、靶点突变机制和酶促水解这四种主要耐药机制，系统分析了沙门氏菌、单核细胞增生李斯特菌和大肠杆菌的耐药性。并探讨了可能用于解决食源性病原体耐药性的新方法，如CRISPR和噬菌体。本综述为食源性疾病的治疗提供了一定的理论依据。
