Peruzy Maria Francesca, Murru Nicoletta, Carullo Maria Rosaria, La Tela Immacolata, Rippa Antonio, Balestrieri Anna, Proroga Yolande Thérèse Rose
Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", Via Delpino 1, 80137 Naples, Italy.
Task Force on Microbiome Studies, University of Naples Federico II, 80138, Naples, Italy.
Antibiotics (Basel). 2025 Feb 12;14(2):189. doi: 10.3390/antibiotics14020189.
: A retrospective study was conducted to evaluate antibiotic resistance among strains isolated during human infection using data from the computer database (SIGLA) of the Typing Center (Ce.Ti.Sa) of the Istituto Zooprofilattico del Mezzogiorno (IZSM). : From 2010 to 2023, the Ce.Ti.Sa laboratory tested 680 strains against the following: amoxicillin/clavulanic acid, ampicillin, azithromycin, cefixime, cefoxitin, cefotaxime, ceftazidime, chloramphenicol, ciprofloxacin, colistin, erythromycin, gentamicin, kanamycin, meropenem, nalidixic acid, pefloxacin, streptomycin, sulfisoxazole, sulfonamides, tetracyclines, tigecycline, and trimethoprim. : The most common serovars were (23.2%), (16.8%), and (16.0%). Nearly all strains were resistant to azithromycin (99.4%) and showed high resistance to sulphonamides, tetracycline, streptomycin, and ampicillin. The study found that 45.8% of strains exhibited multidrug resistance. Resistance to ciprofloxacin increased over time. Serovar-specific resistance varied: was resistant to azithromycin (100.0%), tetracycline (93.0%), and ampicillin (92.4%); showed 100.0% resistance to azithromycin; had high resistance to azithromycin, streptomycin, and ampicillin; and was resistant to erythromycin, sulfonamides, and azithromycin. : The study highlights a troubling prevalence of -resistant strains, emphasizing the need for infection prevention, proper antibiotic use in humans and animals, and the development of new antibiotics.
使用意大利南部动物卫生研究所（IZSM）分型中心（Ce.Ti.Sa）计算机数据库（SIGLA）中的数据，进行了一项回顾性研究，以评估人类感染期间分离出的菌株的抗生素耐药性。：2010年至2023年期间，Ce.Ti.Sa实验室针对以下抗生素对680株菌株进行了测试：阿莫西林/克拉维酸、氨苄西林、阿奇霉素、头孢克肟、头孢西丁、头孢噻肟、头孢他啶、氯霉素、环丙沙星、黏菌素、红霉素、庆大霉素、卡那霉素、美罗培南、萘啶酸、培氟沙星、链霉素、磺胺异恶唑、磺胺类药物、四环素、替加环素和甲氧苄啶。：最常见的血清型是（23.2%）、（16.8%）和（16.0%）。几乎所有菌株都对阿奇霉素耐药（99.4%），并对磺胺类药物、四环素、链霉素和氨苄西林表现出高度耐药性。研究发现，45.8%的菌株表现出多重耐药性。对环丙沙星的耐药性随时间增加。血清型特异性耐药性各不相同：对阿奇霉素（100.0%）、四环素（93.0%）和氨苄西林（92.4%）耐药；对阿奇霉素的耐药率为100.0%；对阿奇霉素、链霉素和氨苄西林具有高度耐药性；对红霉素、磺胺类药物和阿奇霉素耐药。：该研究突出了耐药菌株令人担忧的流行情况，强调了预防感染、在人和动物中合理使用抗生素以及开发新抗生素的必要性。
