Zari Shadi
Department of Dermatology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Clin Cosmet Investig Dermatol. 2021 Nov 19;14:1725-1736. doi: 10.2147/CCID.S334807. eCollection 2021.
Autologous cellular micrografts (ACM) is a novel treatment method in hair loss, and few data are available regarding its efficacy. The present study was carried out to assess the short-term clinical efficacy of a single application of ACM in the treatment of male and female androgenetic alopecia (AGA).
This was a single-center retrospective study involving 140 consecutive adults with confirmed AGA, who received a single session of ACM (Regenera Activa®). Efficacy was evaluated 1-6 months after treatment, by analyzing the change of trichometry parameters, which were assessed using TrichoScan digital image analysis.
Depending on the scalp region, there was increase in mean hair density by 4.5-7.12 hair/cm, average hair thickness by 0.96-1.88 μm, % thick hair by 1.74-3.26%, and mean number of follicular units by 1.30-2.77, resulting in an increase of cumulative hair thickness by 0.48-0.56 unit. Additionally, the frontal region showed a significant decrease in % thin hair (-1.81%, p = 0.037) and yellow dots (-1.93 N/cm, p = 0.003). A favorable response was observed in 66.4% of the participants in the frontal region. Further, a gender-specific effect of treatment was observed.
ACM is a promising treatment in AGA with a short-term favorable response observed in up to approximately two-thirds of patients.
自体细胞微移植（ACM）是一种治疗脱发的新方法，关于其疗效的数据较少。本研究旨在评估单次应用ACM治疗男性和女性雄激素性脱发（AGA）的短期临床疗效。
这是一项单中心回顾性研究，纳入了140例确诊为AGA的连续成年患者，他们接受了单次ACM（Regenera Activa®）治疗。在治疗后1至6个月，通过分析毛发测量参数的变化来评估疗效，这些参数使用TrichoScan数字图像分析进行评估。
根据头皮区域不同，平均头发密度增加了4.5至7.12根/平方厘米，平均头发厚度增加了0.96至1.88微米，粗发百分比增加了1.74至3.26%，毛囊单位平均数增加了1.30至2.77个，累积头发厚度增加了0.48至0.56个单位。此外，额部区域细发百分比显著下降（-1.81%，p = 0.037），黄点数量显著下降（-1.93个/平方厘米，p = 0.003）。在额部区域，66.4%的参与者观察到良好反应。此外，观察到了治疗的性别特异性效应。
ACM是一种有前景的AGA治疗方法，在约三分之二的患者中观察到短期良好反应。
