Carstensen Lucas C, Alexander Andrew S, Chapman G William, Lee Aubrey J, Hasselmo Michael E
Center for Systems Neuroscience, Boston University, 610 Commonwealth Avenue, Boston, MA 02215, USA.
Department of Psychological and Brain Sciences, Boston University, 610 Commonwealth Avenue, Boston, MA 02215, USA.
iScience. 2021 Oct 28;24(11):103377. doi: 10.1016/j.isci.2021.103377. eCollection 2021 Nov 19.
The retrosplenial cortex (RSC) is an area interconnected with regions of the brain that display spatial correlates. Neurons in connected regions may encode an animal's position in the environment and location or proximity to objects or boundaries. RSC has also been shown to be important for spatial memory, such as tracking distance from and between landmarks, contextual information, and orientation within an environment. For these reasons, it is important to determine how neurons in RSC represent cues such as objects or boundaries and their relationship to the environment. In the current work, we performed electrophysiological recordings in RSC, whereas rats foraged in arenas that could contain an object or in which the environment was altered. We report RSC neurons display changes in mean firing rate responding to alterations of the environment. These alterations include the arena rotating, changing size or shape, or an object being introduced into the arena.
retrosplenial皮质（RSC）是一个与显示空间相关性的脑区相互连接的区域。相连区域中的神经元可能编码动物在环境中的位置以及与物体或边界的位置或接近程度。RSC也已被证明对空间记忆很重要，例如跟踪地标之间的距离、情境信息以及环境中的方向。出于这些原因，确定RSC中的神经元如何表征诸如物体或边界等线索及其与环境的关系非常重要。在当前的工作中，我们在RSC中进行了电生理记录，而大鼠在可能包含物体或环境发生改变的场地中觅食。我们报告RSC神经元在平均放电率上显示出对环境改变的反应变化。这些改变包括场地旋转、大小或形状改变，或向场地中引入一个物体。
