Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
BIH Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Corporate Member of Freie-Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
Angew Chem Int Ed Engl. 2022 Feb 14;61(8):e202113833. doi: 10.1002/anie.202113833. Epub 2022 Jan 3.
Novel bionanocatalysts have opened a new era in fighting multidrug-resistant (MDR) bacteria. They can kill bacteria by elevating the level of reactive oxygen species (ROS) in the presence of chemicals like H O . However, ROSs' ultrashort diffusion distance limit their bactericidal activity. We present a nanohook-equipped bionanocatalyst (Ni@Co-NC) with bacterial binding ability that shows robust ROS-generating capacity under physiological H O levels. The Ni@Co-NC's pH-dependent performance confines its effects to the biofilm microenvironment, leaving healthy tissue unaffected. Furthermore, it can generate heat upon NIR laser irradiation, enhancing its catalytic performance while achieving heat ablation against bacteria. With the Ni@Co-NC's synergistic effects, bacterial populations fall by >99.99 %. More surprisingly, the mature biofilm shows no recurrence after treatment with the Ni@Co-NC, demonstrating its tremendous potential for treating MDR bacterial related infections.
新型生物纳米催化剂开创了对抗多药耐药（MDR）细菌的新时代。它们可以通过在 H2O2 等化学物质的存在下提高活性氧（ROS）水平来杀死细菌。然而，ROS 的超短扩散距离限制了它们的杀菌活性。我们提出了一种具有细菌结合能力的纳米钩装备生物纳米催化剂（Ni@Co-NC），它在生理 H2O2 水平下具有强大的 ROS 生成能力。Ni@Co-NC 的 pH 依赖性性能将其作用局限在生物膜微环境中，使健康组织不受影响。此外，它可以在近红外激光照射下产生热量，在实现对细菌的热消融的同时增强其催化性能。Ni@Co-NC 的协同作用使细菌数量减少了>99.99%。更令人惊讶的是，成熟的生物膜在经过 Ni@Co-NC 处理后没有复发，这表明它在治疗 MDR 细菌相关感染方面具有巨大的潜力。
