He Fupo, Qiu Chao, Lu Teliang, Shi Xuetao, Ye Jiandong
School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, People's Republic of China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
Biomed Mater. 2021 Dec 10;17(1). doi: 10.1088/1748-605X/ac3d9a.
Gallium-containing biomaterials are considered promising for reconstructing osteoporotic bone defects, owing to the potent effect of gallium on restraining osteoclast activities. Nevertheless, the gallium-containing biomaterials were demonstrated to disturb the osteoblast activities. In this study, tricalcium phosphate (TCP) bioceramics were modified by gallium doping in conjunction with incorporation of calcium silicate (CS). The results indicated that the incorporation of CS promoted transition of-TCP to-TCP, and accelerated densification process, but did not improve the mechanical strength of bioceramics. The silicon released from the composite bioceramics diminished the inhibition effect of released gallium on osteoblast activities, and maintained its effect on restraining osteoclast activities. The TCP-based bioceramics doped with 2.5 mol% gallium and incorporated with 10 mol% CS are considered suitable for treating the bone defects in the osteoporotic environment.
由于镓在抑制破骨细胞活性方面具有显著作用，含镓生物材料被认为在重建骨质疏松性骨缺损方面具有广阔前景。然而，已证明含镓生物材料会干扰成骨细胞活性。在本研究中，通过镓掺杂并结合硅酸钙（CS）的掺入对磷酸三钙（TCP）生物陶瓷进行了改性。结果表明，CS的掺入促进了β-TCP向α-TCP的转变，并加速了致密化过程，但并未提高生物陶瓷的机械强度。复合生物陶瓷释放的硅减少了释放的镓对成骨细胞活性的抑制作用，并保持了其对破骨细胞活性的抑制作用。掺杂2.5 mol%镓并掺入10 mol% CS的TCP基生物陶瓷被认为适用于治疗骨质疏松环境中的骨缺损。
