The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China; Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou, 730000, Gansu, People's Republic of China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Medical College Cancer Center of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Chemosphere. 2022 Jan;287(Pt 3):132190. doi: 10.1016/j.chemosphere.2021.132190. Epub 2021 Sep 9.
Exposure to both cadmium (Cd) and lead (Pb) can promote systemic inflammation. However, the effects of combined exposure to environmental levels of Cd and Pb on systemic immune inflammation have not been fully clarified. A total of 486 subjects (313 women and 173 men) living in either a control area or heavy metal-polluted area were included. Blood Cd and Pb and immune inflammation biomarkers were determined, including the eosinophil-lymphocyte ratio (ELR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and systemic immune-inflammation index (SII); moreover, the associations between exposure markers and systemic inflammation markers were analysed. The exposure levels in the polluted area were significantly higher than those in the control area. The NLR, PLR, and SII of subjects in the polluted area were higher and the LMR was lower than in the control area. Blood Pb and Cd levels are associated with elevated or decreased immune inflammation biomarkers in subjects from the exposed and control areas. Furthermore, co-exposure to both Cd and Pb was divided into high, middle, and low exposure groups. The subjects in the high co-exposure group displayed higher levels of ELR, NLR, and SII compared with the middle and low co-exposure group, and LMR levels displayed the opposite trend. Our data demonstrate that Cd and Pb co-exposure is associated with systemic immune inflammation, and the immune inflammatory response is aggravated with an increased co-exposure to Cd and Pb.
暴露于镉 (Cd) 和铅 (Pb) 均可促进全身炎症。然而，环境水平的 Cd 和 Pb 联合暴露对全身免疫炎症的影响尚未完全阐明。共纳入居住在对照区或重金属污染区的 486 名受试者（313 名女性和 173 名男性）。测定血 Cd 和 Pb 及免疫炎症生物标志物，包括嗜酸性粒细胞-淋巴细胞比值（ELR）、中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）、淋巴细胞-单核细胞比值（LMR）和全身免疫炎症指数（SII）；此外，分析了暴露标志物与全身炎症标志物之间的关系。污染区的暴露水平明显高于对照区。污染区受试者的 NLR、PLR 和 SII 高于对照区，而 LMR 则低于对照区。血 Pb 和 Cd 水平与暴露区和对照区受试者的免疫炎症标志物升高或降低有关。此外，将 Cd 和 Pb 的共同暴露分为高、中、低暴露组。与中、低共同暴露组相比，高共同暴露组的 ELR、NLR 和 SII 水平更高，而 LMR 水平则呈现相反的趋势。我们的数据表明，Cd 和 Pb 的共同暴露与全身免疫炎症有关，并且随着 Cd 和 Pb 共同暴露的增加，免疫炎症反应加剧。
