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担子菌粗提物抗菌活性的系统研究

A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts.

作者信息

Clericuzio Marco, Bivona Mattia, Gamalero Elisa, Bona Elisa, Novello Giorgia, Massa Nadia, Dovana Francesco, Marengo Emilio, Robotti Elisa

机构信息

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, AL, Italy.

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Piazza San Eusebio 5, 13100 Vercelli, VC, Italy.

出版信息

Antibiotics (Basel). 2021 Nov 21;10(11):1424. doi: 10.3390/antibiotics10111424.

DOI:10.3390/antibiotics10111424
PMID:34827362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8615167/
Abstract

The excessive consumption of antibiotics in clinical, veterinary and agricultural fields has resulted in tremendous flow of antibiotics into the environment. This has led to enormous selective pressures driving the evolution of antimicrobial resistance genes in pathogenic and commensal bacteria. In this context, the World Health Organization (WHO) has promoted research aiming to develop medical features using natural products that are often competitive with synthetic drugs in clinical performance. Fungi are considered an important source of bioactive molecules, often effective against other fungi and/or bacteria, and thus are potential candidates in the search of new antibiotics. Fruiting bodies of sixteen different fungal species of Basidiomycota were collected in the Italian Alps. The identification of fungal species was performed through Internal Transcribed Spacer (ITS) sequencing. Most species belong to genera , and , whose metabolite contents has been scarcely investigated so far. The crude extracts obtained from the above mushrooms were tested for their inhibition activity against five human pathogens: ATCC 14053, ATCC 15126, NCTC 6571, ATCC 27853 and ATCC 13883. Twelve crude extracts showed activity against ATCC 27853. Highest activity was shown by some species, as .

摘要

临床、兽医和农业领域抗生素的过度使用导致大量抗生素流入环境。这产生了巨大的选择压力，推动致病细菌和共生细菌中抗菌抗性基因的进化。在此背景下，世界卫生组织（WHO）推动了旨在利用天然产物开发医学特性的研究，这些天然产物在临床性能上往往可与合成药物相媲美。真菌被认为是生物活性分子的重要来源，通常对其他真菌和/或细菌有效，因此是寻找新抗生素的潜在候选者。在意大利阿尔卑斯山采集了16种不同担子菌纲真菌的子实体。通过内转录间隔区（ITS）测序对真菌物种进行鉴定。大多数物种属于 、 和 属，到目前为止，对其代谢物含量的研究很少。对上述蘑菇获得的粗提物进行了针对五种人类病原体的抑制活性测试：ATCC 14053、ATCC 15126、NCTC 6571、ATCC 27853和ATCC 13883。12种粗提物对ATCC 27853显示出活性。一些 属物种表现出最高活性，如 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/4c5a232da669/antibiotics-10-01424-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/9440c1187268/antibiotics-10-01424-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/bf2c6ac77a06/antibiotics-10-01424-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/b30ea0aa5480/antibiotics-10-01424-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/334190166d9c/antibiotics-10-01424-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/3842d39ce8fc/antibiotics-10-01424-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/d7aec93969cd/antibiotics-10-01424-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/4c5a232da669/antibiotics-10-01424-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/9440c1187268/antibiotics-10-01424-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/bf2c6ac77a06/antibiotics-10-01424-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/b30ea0aa5480/antibiotics-10-01424-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/334190166d9c/antibiotics-10-01424-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/3842d39ce8fc/antibiotics-10-01424-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/d7aec93969cd/antibiotics-10-01424-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ede/8615167/4c5a232da669/antibiotics-10-01424-g007.jpg

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