Arrais Aldo, Testori Fabio, Calligari Roberta, Gianotti Valentina, Roncoli Maddalena, Caramaschi Alice, Todeschini Valeria, Massa Nadia, Bona Elisa
Dipartimento per lo Sviluppo Sostenibile e la Transizione Ecologica, Università del Piemonte Orientale, 13100 Vercelli, Italy.
Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, 15121 Alessandria, Italy.
Biology (Basel). 2022 Jul 20;11(7):1080. doi: 10.3390/biology11071080.
As dramatically experienced in the recent world pandemic, viral, bacterial, fungal pathogens constitute very serious concerns in the global context of human health. Regarding this issue, the World Health Organization has promoted research studies that aim to develop new strategies using natural products. Although they are often competitive with synthetic pharmaceuticales in clinical performance, they lack their critical drawbacks, i.e., the environmental impact and the high economic costs of processing. In this paper, the isolation of a highly performant antibacterial and antifungal lipophilic natural mixture from leaves of savoy and white cabbages is proposed as successful preliminary results for the valorization of agricultural waste produced in cabbage cultivation. The fraction was chemically extracted from vegetables with diethyl ether and tested against two species, as well as , and reference strains. All the different fractions (active and not active) were chemically characterized by vibrational FT-IR spectroscopy and GC-MS analyses. The extracts showed high growth-inhibition performance on pathogens, thus demonstrating strong application potential. We think that this work, despite being at a preliminary stage, is very promising, both from pharmaceutical and industrial points of view, and can be proposed as a proof of concept for the recovery of agricultural production wastes.
正如在最近的全球大流行中所深刻体验到的那样，病毒、细菌、真菌病原体在全球人类健康背景下构成了非常严重的问题。关于这个问题，世界卫生组织推动了旨在利用天然产物开发新策略的研究。尽管它们在临床性能上常常与合成药物相媲美，但它们没有合成药物的关键缺点，即对环境的影响和加工的高经济成本。在本文中，从皱叶甘蓝和结球甘蓝叶片中分离出一种高效的抗菌和抗真菌亲脂性天然混合物，作为甘蓝种植中产生的农业废弃物增值利用的成功初步成果被提出。该馏分用乙醚从蔬菜中化学提取，并针对两种菌株以及参考菌株进行了测试。所有不同的馏分（活性和非活性）都通过振动傅里叶变换红外光谱和气相色谱 - 质谱分析进行了化学表征。提取物对病原体表现出高生长抑制性能，从而证明了强大的应用潜力。我们认为，这项工作尽管处于初步阶段，但从制药和工业角度来看都非常有前景，并且可以作为农业生产废弃物回收利用的概念验证被提出。
