Toll样受体介导的信号转导与神经退行性疾病
TLR-Mediated Signal Transduction and Neurodegenerative Disorders.
作者信息
Adhikarla Shashank Vishwanath, Jha Niraj Kumar, Goswami Vineet Kumar, Sharma Ankur, Bhardwaj Anuradha, Dey Abhijit, Villa Chiara, Kumar Yatender, Jha Saurabh Kumar
机构信息
Department of Biological Sciences and Engineering, Netaji Subhas University of Technology (Formerly NSIT, University of Delhi), New Delhi 110078, India.
Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201310, India.
出版信息
Brain Sci. 2021 Oct 20;11(11):1373. doi: 10.3390/brainsci11111373.
A special class of proteins called Toll-like receptors (TLRs) are an essential part of the innate immune system, connecting it to the adaptive immune system. There are 10 different Toll-Like Receptors that have been identified in human beings. TLRs are part of the central nervous system (CNS), showing that the CNS is capable of the immune response, breaking the long-held belief of the brain's "immune privilege" owing to the blood-brain barrier (BBB). These Toll-Like Receptors are present not just on the resident macrophages of the central nervous system but are also expressed by the neurons to allow them for the production of proinflammatory agents such as interferons, cytokines, and chemokines; the activation and recruitment of glial cells; and their participation in neuronal cell death by apoptosis. This study is focused on the potential roles of various TLRs in various neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD), namely TLR2, TLR3, TLR4, TLR7, and TLR9 in AD and PD in human beings and a mouse model.
一类特殊的蛋白质，称为Toll样受体（TLR），是先天免疫系统的重要组成部分，将先天免疫系统与适应性免疫系统联系起来。人类已鉴定出10种不同的Toll样受体。Toll样受体是中枢神经系统（CNS）的一部分，这表明中枢神经系统能够产生免疫反应，打破了长期以来由于血脑屏障（BBB）而认为大脑具有“免疫特权”的观念。这些Toll样受体不仅存在于中枢神经系统的驻留巨噬细胞上，神经元也会表达，使神经元能够产生促炎因子，如干扰素、细胞因子和趋化因子；激活和募集神经胶质细胞；并通过凋亡参与神经元细胞死亡。本研究聚焦于各种Toll样受体在帕金森病（PD）和阿尔茨海默病（AD）等各种神经退行性疾病中的潜在作用，即人类和小鼠模型中AD和PD中的TLR2、TLR3、TLR4、TLR7和TLR9。
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