Lebda Mohamed A, Mostafa Rabab E, Taha Nabil M, Abd El-Maksoud Eman M, Tohamy Hossam G, Al Jaouni Soad K, El-Far Ali H, Elfeky Mohamed S
Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria 21526, Egypt.
Pathology Department, Faculty of Veterinary Medicine, Alexandria University, Alexandria 21526, Egypt.
Antioxidants (Basel). 2021 Nov 19;10(11):1836. doi: 10.3390/antiox10111836.
Gastric ulceration is a multifactorial disease defined as a defect in the gastric wall that extends through the muscularis mucosae into the deeper layers of the wall. The most common cause of gastric ulceration is alcohol consumption. In the current study, rats were gavaged by ethanol to investigate the protective (before ethanol) and curative (after ethanol) ability of (myrrh) oil and extract against gastric ulcer oxidative alterations induced by ethanol. Myrrh significantly improved ulcer index, histomorphology, and periodic acid Schiff (PAS) impaired by ethanol. In addition, myrrh improved the antioxidant potential of gastric mucosa through enhancement of nuclear factor related to erythroid 2 (Nrf2), total glutathione (GSH), reduced GSH, and oxidized glutathione (GSSG), along with significant reduction in malondialdehyde (MDA) levels. Amelioration of gastric oxidative stress by myrrh enables gastric mucosa to counteract the ethanol's inflammatory and apoptotic processes leading to improved gastric proliferation and healing. Interestingly, myrrh extract showed better protective and curative effects than myrrh oil against gastric ulceration.
胃溃疡是一种多因素疾病，定义为胃壁上的缺损，该缺损穿过黏膜肌层延伸至胃壁更深层。胃溃疡最常见的病因是饮酒。在本研究中，给大鼠灌胃乙醇，以研究没药油和提取物对乙醇诱导的胃溃疡氧化改变的预防（乙醇灌胃前）和治疗（乙醇灌胃后）能力。没药显著改善了乙醇损伤的溃疡指数、组织形态学和过碘酸希夫（PAS）染色结果。此外，没药通过增强与红系2相关的核因子（Nrf2）、总谷胱甘肽（GSH）、还原型谷胱甘肽和氧化型谷胱甘肽（GSSG），同时显著降低丙二醛（MDA）水平，提高了胃黏膜的抗氧化能力。没药改善胃氧化应激，使胃黏膜能够对抗乙醇的炎症和凋亡过程，从而促进胃的增殖和愈合。有趣的是，在预防和治疗胃溃疡方面，没药提取物比没药油表现出更好的效果。
