Program of Post-Graduation in Chemistry, Federal University of Pará, Belém, Brazil.
Adolpho Ducke Laboratory, Paraense Emílio Goeldi Museum, Belém, Brazil.
Nat Prod Res. 2022 Aug;36(15):4009-4012. doi: 10.1080/14786419.2021.1893724. Epub 2021 Mar 7.
In the present study, the essential oil (EO) of DC. or was extracted by hydrodistillation, and the identification and quantification of volatile compounds were performed by GC-MS and GC-FID. leaves were collected from the Magalhães Barata, northeast of the State of Pará (Brazil) in March and September of 2019. Moreover, we used computational approaches to evaluate possible biological targets for the major compounds of the EO. In the sample obtained in March, 50 compounds were identified, with hydrocarbon sesquiterpenes being the predominant ones with the content of 80.52%. In the sample collected in September, 58 compounds were identified, and the chemical class of hydrocarbon monoterpenes and sesquiterpenes were the dominant ones with contents of 43.36 and 31.29%, respectively. Computational methods demonstrated that some major compounds have potential biological activity against some strains of pathogenic bacteria, as well as against molecular targets involved in cancer development.
本研究采用水蒸馏法从 DC. 或 中提取精油（EO），并通过 GC-MS 和 GC-FID 对挥发性化合物进行鉴定和定量。 于 2019 年 3 月和 9 月在巴西帕拉州东北部的马加良斯·巴拉塔（Magalhães Barata）收集了叶子。 此外，我们还使用计算方法来评估 EO 中主要化合物的可能生物学靶标。 在 3 月获得的样品中，鉴定出 50 种化合物，其中碳氢化合物倍半萜是主要成分，含量为 80.52%。 在 9 月采集的样品中，鉴定出 58 种化合物，碳氢化合物单萜和倍半萜是主要成分，含量分别为 43.36%和 31.29%。 计算方法表明，一些主要化合物对一些病原菌菌株以及参与癌症发展的分子靶标具有潜在的生物活性。
