Key Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Int J Mol Sci. 2021 Nov 12;22(22):12271. doi: 10.3390/ijms222212271.
Phase-separated condensates participate in various biological activities. Liquid-liquid phase separation (LLPS) can be driven by collective interactions between multivalent and intrinsically disordered proteins. The manner in which chromatin-with various morphologies and activities-is organized in a complex and small nucleus still remains to be fully determined. Recent findings support the claim that phase separation is involved in the regulation of chromatin organization and chromosome behavior. Moreover, phase separation also influences key events during mitosis and meiosis. This review elaborately dissects how phase separation regulates chromatin and chromosome organization and controls mitotic and meiotic chromosome behavior.
相分离凝聚物参与各种生物活动。液-液相分离（LLPS）可以由多价和固有无序蛋白质之间的集体相互作用驱动。染色质以各种形态和活性在复杂和小的核中组织的方式仍有待完全确定。最近的发现支持这样的观点，即相分离参与了染色质组织和染色体行为的调节。此外，相分离也会影响有丝分裂和减数分裂过程中的关键事件。这篇综述详细剖析了相分离如何调节染色质和染色体组织，并控制有丝分裂和减数分裂染色体行为。
